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- W2499453181 abstract "Separate design strategies for immunizing haptens and labeled competitor reagents are critical to the development of sensitive and specific immunoassays. Immunoassay development has generally focused on hapten and competitor designs which faithfully mimic the target analyte and vary mainly in the attachment site, chain length and functional groups of the spacer arm. We have investigated the concept that while the immunizing hapten defines assay specificity, it is the labeled competitor which determines sensitivity. Thus it is not an inherent assay development requirement that the labeled competitor substantially duplicate the analyte. The development of a polychlorinated biphenyl (PCB) immunoassay is described which uses a core heterology approach, in which the competitor is a structural fragment of the analyte, to maximize analyte sensitivity while retaining assay specificity." @default.
- W2499453181 created "2016-08-23" @default.
- W2499453181 creator A5017295979 @default.
- W2499453181 date "1995-03-23" @default.
- W2499453181 modified "2023-09-25" @default.
- W2499453181 title "Hapten Versus Competitor Design Strategies for Immunoassay Development" @default.
- W2499453181 doi "https://doi.org/10.1021/bk-1995-0586.ch010" @default.
- W2499453181 hasPublicationYear "1995" @default.
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