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• W2499454019 abstract "Cancer stem‐like cells (CSCs) are thought to be the main cause of tumor occurrence, progression and therapeutic resistance. Strong research efforts in the last decade have led to the development of several tailored approaches to target CSCs with some very promising clinical trials underway; however, until now no anti‐CSC therapy has been approved for clinical use. Given the recent improvement in our understanding of how onco‐proteins can manipulate cellular metabolic networks to promote tumorigenesis, cancer metabolism research may well lead to innovative strategies to identify novel regulators and downstream mediators of CSC maintenance. Interfering with distinct stages of CSC‐associated metabolics may elucidate novel, more efficient strategies to target this highly malignant cell population. Here recent discoveries regarding the metabolic properties attributed to CSCs in glioblastoma (GBM) and malignant colorectal cancer (CRC) were summarized. The association between stem cell markers, the response to hypoxia and other environmental stresses including therapeutic insults as well as developmentally conserved signaling pathways with alterations in cellular bioenergetic networks were also discussed. The recent developments in metabolic imaging to identify CSCs were also summarized. This summary should comprehensively update basic and clinical scientists on the metabolic traits of CSCs in GBM and malignant CRC." @default.
• W2499454019 created "2016-08-23" @default.
• W2499454019 creator A5002132896 @default.
• W2499454019 creator A5008627959 @default.
• W2499454019 creator A5032518739 @default.
• W2499454019 creator A5040312682 @default.
• W2499454019 creator A5060055762 @default.
• W2499454019 date "2016-07-20" @default.
• W2499454019 modified "2023-10-14" @default.
• W2499454019 title "Targeting cancer stem‐like cells in glioblastoma and colorectal cancer through metabolic pathways" @default.
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