Matches in SemOpenAlex for { <https://semopenalex.org/work/W2499482813> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2499482813 endingPage "195" @default.
- W2499482813 startingPage "191" @default.
- W2499482813 abstract "The Hand, Foot and Mouth Disease (HFMD) can result from infections by a plethora of human enteroviruses of the species Enterovirus A and B. These infections are highly contagious, resulting in regular outbreaks especially in the Asia-Pacific Region in the recent decade. Although this disease is generally a childhood affliction which manifests as a mild, febrile illness accompanied by the vesicles on the hands, feet and mouth, permanent morbidity or even fatality can result from severe forms of the disease in a subset of the infected patients. The N-terminal myristoylation signal (MGXXXS) of viral capsid protein VP4, one of the four viral structural proteins, is an extremely well conserved feature of enteroviruses, a potential antiviral target that may yield broad-spectrum inhibitors of HFMD. In this study, we have confirmed through the use of small interfering RNAs, human N-myristoyltransferase 1 plays an integral role in human Enterovirus 71 replication. Subsequent studies by inhibition of myristoylation using different myristic acid analogues elicited differential effects on the virus replication in human rhabdomyosarcoma cells. In particular, 2-hydroxymyristic acid specifically inhibited the cleavage between VP4 and VP2, part of the virion maturation process required to ensure infectivity of progeny virions while 4-oxatetradecanoic acid reduced the synthesis of viral RNA. These findings suggest that the requirement of a myristate moiety in viral structural protein precursor cleavage can serve as a viable antiviral target for further research." @default.
- W2499482813 created "2016-08-23" @default.
- W2499482813 creator A5021598141 @default.
- W2499482813 creator A5064691389 @default.
- W2499482813 creator A5067662187 @default.
- W2499482813 date "2016-09-01" @default.
- W2499482813 modified "2023-09-23" @default.
- W2499482813 title "Inhibition of enterovirus VP4 myristoylation is a potential antiviral strategy for hand, foot and mouth disease" @default.
- W2499482813 cites W1588502587 @default.
- W2499482813 cites W1946374406 @default.
- W2499482813 cites W1958494624 @default.
- W2499482813 cites W1968892227 @default.
- W2499482813 cites W1974315905 @default.
- W2499482813 cites W1991324563 @default.
- W2499482813 cites W1995299045 @default.
- W2499482813 cites W2023714135 @default.
- W2499482813 cites W2070283392 @default.
- W2499482813 cites W2073018427 @default.
- W2499482813 cites W2110336165 @default.
- W2499482813 cites W2110599330 @default.
- W2499482813 cites W2139727003 @default.
- W2499482813 cites W2150633180 @default.
- W2499482813 cites W2238228203 @default.
- W2499482813 cites W2248519466 @default.
- W2499482813 cites W2412782587 @default.
- W2499482813 cites W4254289566 @default.
- W2499482813 cites W4368128916 @default.
- W2499482813 doi "https://doi.org/10.1016/j.antiviral.2016.08.009" @default.
- W2499482813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27520386" @default.
- W2499482813 hasPublicationYear "2016" @default.
- W2499482813 type Work @default.
- W2499482813 sameAs 2499482813 @default.
- W2499482813 citedByCount "19" @default.
- W2499482813 countsByYear W24994828132017 @default.
- W2499482813 countsByYear W24994828132018 @default.
- W2499482813 countsByYear W24994828132019 @default.
- W2499482813 countsByYear W24994828132020 @default.
- W2499482813 countsByYear W24994828132021 @default.
- W2499482813 countsByYear W24994828132022 @default.
- W2499482813 countsByYear W24994828132023 @default.
- W2499482813 crossrefType "journal-article" @default.
- W2499482813 hasAuthorship W2499482813A5021598141 @default.
- W2499482813 hasAuthorship W2499482813A5064691389 @default.
- W2499482813 hasAuthorship W2499482813A5067662187 @default.
- W2499482813 hasConcept C106358424 @default.
- W2499482813 hasConcept C11960822 @default.
- W2499482813 hasConcept C140704245 @default.
- W2499482813 hasConcept C159047783 @default.
- W2499482813 hasConcept C202878990 @default.
- W2499482813 hasConcept C2522874641 @default.
- W2499482813 hasConcept C2777888124 @default.
- W2499482813 hasConcept C2778483698 @default.
- W2499482813 hasConcept C2778889330 @default.
- W2499482813 hasConcept C2779070877 @default.
- W2499482813 hasConcept C2779120600 @default.
- W2499482813 hasConcept C2779936771 @default.
- W2499482813 hasConcept C543025807 @default.
- W2499482813 hasConcept C55493867 @default.
- W2499482813 hasConcept C77207865 @default.
- W2499482813 hasConcept C86803240 @default.
- W2499482813 hasConcept C95444343 @default.
- W2499482813 hasConceptScore W2499482813C106358424 @default.
- W2499482813 hasConceptScore W2499482813C11960822 @default.
- W2499482813 hasConceptScore W2499482813C140704245 @default.
- W2499482813 hasConceptScore W2499482813C159047783 @default.
- W2499482813 hasConceptScore W2499482813C202878990 @default.
- W2499482813 hasConceptScore W2499482813C2522874641 @default.
- W2499482813 hasConceptScore W2499482813C2777888124 @default.
- W2499482813 hasConceptScore W2499482813C2778483698 @default.
- W2499482813 hasConceptScore W2499482813C2778889330 @default.
- W2499482813 hasConceptScore W2499482813C2779070877 @default.
- W2499482813 hasConceptScore W2499482813C2779120600 @default.
- W2499482813 hasConceptScore W2499482813C2779936771 @default.
- W2499482813 hasConceptScore W2499482813C543025807 @default.
- W2499482813 hasConceptScore W2499482813C55493867 @default.
- W2499482813 hasConceptScore W2499482813C77207865 @default.
- W2499482813 hasConceptScore W2499482813C86803240 @default.
- W2499482813 hasConceptScore W2499482813C95444343 @default.
- W2499482813 hasLocation W24994828131 @default.
- W2499482813 hasLocation W24994828132 @default.
- W2499482813 hasOpenAccess W2499482813 @default.
- W2499482813 hasPrimaryLocation W24994828131 @default.
- W2499482813 hasRelatedWork W1955329737 @default.
- W2499482813 hasRelatedWork W2012539582 @default.
- W2499482813 hasRelatedWork W2021304817 @default.
- W2499482813 hasRelatedWork W2024338687 @default.
- W2499482813 hasRelatedWork W2051415673 @default.
- W2499482813 hasRelatedWork W2094885992 @default.
- W2499482813 hasRelatedWork W2118643721 @default.
- W2499482813 hasRelatedWork W2499482813 @default.
- W2499482813 hasRelatedWork W2885656504 @default.
- W2499482813 hasRelatedWork W3087172442 @default.
- W2499482813 hasVolume "133" @default.
- W2499482813 isParatext "false" @default.
- W2499482813 isRetracted "false" @default.
- W2499482813 magId "2499482813" @default.
- W2499482813 workType "article" @default.