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- W2499499033 abstract "This chapter examines ethical concerns posed by one form of psychiatric research, the “challenge study,” whereby investigators administer a psychopharmacological agent or psychological challenge procedure to patients under controlled conditions to probe psychiatric symptoms and other neurobiological responses. The principal scientific rationale behind the “challenge study,” or “psychiatric symptom-provoking study,” is to learn more about the underlying pathophysiological mechanisms responsible for the symptomatic expression of psychiatric disorders. In addition, the knowledge gained from this type of study might lead to better predictors of treatment response or the identification of novel therapeutic interventions. The chapter considers two issues related to psychiatric symptom-provoking studies and which have important implications for research ethics: informed consent and risk-benefit ratio. It also recommends guidelines for the design of psychiatric symptom-provoking studies and their review by institutional review boards." @default.
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- W2499499033 date "2012-11-15" @default.
- W2499499033 modified "2023-09-24" @default.
- W2499499033 title "Psychiatric symptom–provoking studies" @default.
- W2499499033 doi "https://doi.org/10.1093/acprof:osobl/9780199896202.003.0004" @default.
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