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• W2499517220 abstract "<b><i>Background:</i></b> Posttransplantation diabetes mellitus (PTDM) is an important metabolic complication after renal transplantation. Activation of the innate immune system via toll-like receptors (TLRs) is implicated in the pathogenesis of insulin resistance and deficiency. Although links between diabetes, dysregulated innate immune responses, and the TLR signaling pathway have been reported, no study so far has investigated their associations with PTDM. In this study, we ascertained whether single nucleotide polymorphisms (SNPs) in TLRs are associated with PTDM in the Korea population. <b><i>Methods:</i></b> A total of 305 patients who received renal transplants without previously diagnosed diabetes were included. We analyzed the association between PTDM development and 6 SNPs within 2 genes of <i>TLR2</i>, 1 gene of <i>TLR4</i>, and 3 genes of <i>TRL6</i>. <b><i>Results:</i></b> Of 305 patients, PTDM developed in 51 patients (16.6%). Patients in the PTDM group were older than those in the non-PTDM group (45.56 ± 1.28 vs. 38.28 ± 0.71 years). Patients with PTDM had significantly higher allele frequency compared to those without PTDM for the <i>TLR</i>4 rs1927914*T, <i>TLR6 </i>rs3775073*A, <i>TLR6</i> rs3821985*C, and <i>TLR6</i> rs1039559*C alleles. Of the 6 SNPs, rs1927914 in the <i>TLR4</i> gene and rs1039559 in the <i>TLR6</i> gene were significantly associated with the development of PTDM after adjustment for age, gender, and tacrolimus usage. <b><i>Conclusions:</i></b> Our study demonstrates a significant association between SNPs<i> rs1927914</i> in <i>TLR4</i> and rs1039559 in <i>TLR6</i> and PTDM in the renal transplantation recipient group. These data suggest that the activation of the innate immune system and inflammation via TLR activation might have an essential role in the pathogenesis of PTDM in renal transplantation." @default.
• W2499517220 created "2016-08-23" @default.
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• W2499517220 date "2016-01-01" @default.
• W2499517220 modified "2023-10-13" @default.
• W2499517220 title "Significant Association between Toll-Like Receptor Gene Polymorphisms and Posttransplantation Diabetes Mellitus" @default.
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• W2499517220 doi "https://doi.org/10.1159/000446570" @default.
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