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- W2499532004 abstract "Advances in genomics and molecular biology have led, over the last decade, to the identification of numerous molecules that form the phagocytic machinery of the retinal pigment epithelium (RPE). This research has also shown that the RPE phagocytic mechanism belongs to a group of related clearance mechanisms that share common phagocytic receptors. However, the precise roles of any of these receptors in the daily phagocytic burst characteristic of the RPE remain to be explored. Here, we focus on contributions of the integrin receptor αvβ5 to outer segment phagocytosis by RPE cells. In vitro functional assays and developmental expression studies indicate an important function for αvβ5 receptors in phagocytosis by human, rat, and mouse RPE. We discuss recent evidence that signaling pathways via αvβ5 integrin in both directions across the RPE plasma membrane may promote synchronized, timely, and repeated phagocytosis unique to RPE. αvβ5 integrin engagement initiates a downstream signaling response that may serve to coordinate the activity of multiple components of the RPE phagocytic machinery. Furthermore, regulation of activities of αvβ5 integrin receptors themselves by RPE signaling mechanisms may prevent phagocytosis by RPE cells upon completion of their daily clearance of shed photoreceptor outer segment fragments." @default.
- W2499532004 created "2016-08-23" @default.
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- W2499532004 date "2004-08-01" @default.
- W2499532004 modified "2023-10-16" @default.
- W2499532004 title "Roles of Integrin Receptors in the Daily Phagocytosis of Photoreceptor Outer Segment Fragments by the RPE" @default.
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- W2499532004 doi "https://doi.org/10.1142/9789812561756_0014" @default.
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