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- W2499546075 abstract "This chapter focuses on estrogens and their involvement in carcinogenesis and the role of antiestrogens as antitumor drugs. Steroid hormone receptors are cytoplasmic or nuclear proteins that have a binding site for a particular steroid molecule. Their response elements are DNA sequences that bind to the complex formed by the steroid and its receptor and are part of a gene promoter. Estrogens are a family of related steroidal molecules that stimulate the development and maintenance of female characteristics and sexual reproduction, including regulation of the menstrual cycle, and have several other physiological functions. The estrogen receptor (ER) is a ligand-dependent transcription factor, that is, a DNA-binding protein that regulates the transcription of its target genes. The link between ovarian function and breast cancer has been known for more than a century, and endocrine therapy can be considered as the oldest, safest, and best-established systemic treatment for breast cancer. Androgens are steroidal hormones that stimulate and control the masculine primary and secondary characteristics. They exert their action by binding to a nuclear receptor called the androgen receptor (AR) and the complex acts as a transcription factor, in a similar way to estrogens." @default.
- W2499546075 created "2016-08-23" @default.
- W2499546075 creator A5037562938 @default.
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- W2499546075 date "2008-01-01" @default.
- W2499546075 modified "2023-09-30" @default.
- W2499546075 title "Anticancer Drugs That Inhibit Hormone Action" @default.
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- W2499546075 doi "https://doi.org/10.1016/b978-0-444-52824-7.00003-2" @default.
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