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- W2499546908 abstract "Frontotemporal dementia (FTD) is a progressive neurodegenerative brain disorder, clinically characterized by changes in cognition, personality, and behavior, or changes in language skills. Marked disturbances in eating behavior, such as overeating and preference for sweet foods, are commonly reported in two of the three main subtypes: the behavioral variant of FTD and semantic dementia. This chapter reviews the current literature on eating abnormalities in FTD, their clinical characteristics, and their biological correlates. Existing literature shows that disturbance in an orbitofrontal-insular-striatal brain network underlies the emergence of eating disturbance in FTD. In addition, recent evidence indicates that degeneration and consequent dysregulation within the hypothalamus relate to significant feeding disturbance in the behavioral variant of FTD. These findings could provide a basis for the development of therapeutic models of this debilitating feature in FTD, which results in significant caregiver burden and possibly contributes to disease progression." @default.
- W2499546908 created "2016-08-23" @default.
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- W2499546908 date "2015-01-01" @default.
- W2499546908 modified "2023-10-17" @default.
- W2499546908 title "Eating Disturbance in Frontotemporal Dementia" @default.
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- W2499546908 doi "https://doi.org/10.1016/b978-0-12-407824-6.00045-8" @default.
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