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• W2499573208 abstract "Abstract Background Treatment of recurrent oropharyngeal cancer is widely thought to have poor outcomes. Justification for treatment, especially in advanced cases, can be difficult. Methods A systematic search of MEDLINE, Embase, and Cochrane databases was conducted. Included studies reported specific recurrent oropharyngeal cancer survival data. Results Twenty‐two retrospective studies were included. Pooled 3‐year overall survival (OS) was 26% (95% confidence interval [CI] = 22% to 29%; I squared = 40.7%; p = .057). Pooled 5‐year OS was 23% (95% CI = 20% to 27%; I squared = 73.9%; p = .000). Surgical treatment was superior to radiation (5‐year OS 26% vs 16%, respectively; p < .001). The 5‐year OS improved over time: 18% in the pre‐2000 cohort; 35% in the mixed pre‐2000 and post‐2000 group; and 51% in the post‐2000 cohort ( p < .001). Conclusion Outcomes have improved considerably over the last 2 decades, resulting in approximately 50% overall 5‐year survival. Human papillomavirus (HPV) status, patient selection, and improvements in care may explain this. © 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck , 2016 © 2016 Wiley Periodicals, Inc. Head Neck 38: 1855–1861, 2016" @default.
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• W2499573208 date "2016-07-13" @default.
• W2499573208 modified "2023-10-15" @default.
• W2499573208 title "Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: A systematic review and meta‐analysis" @default.
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• W2499573208 doi "https://doi.org/10.1002/hed.24531" @default.
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