Matches in SemOpenAlex for { <https://semopenalex.org/work/W2499579077> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2499579077 endingPage "662" @default.
- W2499579077 startingPage "647" @default.
- W2499579077 abstract "This chapter focuses on the appropriate design and performance of clinical trials for neural repair. Clinical trial designs fall into two categories—cross-over design and parallel-group design. Cross-over designs may be more appropriate for presumed symptomatic treatments in patients with nonprogressive illness such as chronic spinal cord injury and parallel group designs may be preferable for neurodegenerative diseases. The choice of a trial's primary and secondary outcome measures is an essential feature of designing clinical trials, especially when trying to assess the value of neuroregenerative therapies. The outcome measures must be chosen based on the expected effect of the therapeutic intervention. Therapeutic trials aim at preventing disease, reduce the rate of progression, or ameliorate symptoms of the disease without altering its underlying structural pathology. The chapter discusses how these various therapeutic aims can be incorporated into the study design. Trials involving agents for which symptomatic improvement of the disease is the objective should examine a common and relevant core symptom of the disease." @default.
- W2499579077 created "2016-08-23" @default.
- W2499579077 creator A5014646926 @default.
- W2499579077 creator A5055508729 @default.
- W2499579077 date "1999-01-01" @default.
- W2499579077 modified "2023-09-23" @default.
- W2499579077 title "Designing Clinical Trials for Neural Repair" @default.
- W2499579077 cites W1164896577 @default.
- W2499579077 cites W1498668468 @default.
- W2499579077 cites W1953027527 @default.
- W2499579077 cites W1972294144 @default.
- W2499579077 cites W1972954420 @default.
- W2499579077 cites W1991952617 @default.
- W2499579077 cites W1994197596 @default.
- W2499579077 cites W1996776294 @default.
- W2499579077 cites W2003308998 @default.
- W2499579077 cites W2006224842 @default.
- W2499579077 cites W2008966172 @default.
- W2499579077 cites W2015951476 @default.
- W2499579077 cites W2020961258 @default.
- W2499579077 cites W2035794396 @default.
- W2499579077 cites W2035986126 @default.
- W2499579077 cites W2047158766 @default.
- W2499579077 cites W2055453667 @default.
- W2499579077 cites W2056046133 @default.
- W2499579077 cites W2057679568 @default.
- W2499579077 cites W2066843577 @default.
- W2499579077 cites W2067418199 @default.
- W2499579077 cites W2085165928 @default.
- W2499579077 cites W2087883935 @default.
- W2499579077 cites W2107557433 @default.
- W2499579077 cites W2128529067 @default.
- W2499579077 cites W2155087576 @default.
- W2499579077 cites W2193764494 @default.
- W2499579077 cites W2301404923 @default.
- W2499579077 cites W2314133009 @default.
- W2499579077 cites W2314689571 @default.
- W2499579077 cites W2326200998 @default.
- W2499579077 cites W2410043158 @default.
- W2499579077 cites W2416100884 @default.
- W2499579077 cites W2466124716 @default.
- W2499579077 cites W599661172 @default.
- W2499579077 cites W899121632 @default.
- W2499579077 doi "https://doi.org/10.1016/b978-012705070-6/50027-5" @default.
- W2499579077 hasPublicationYear "1999" @default.
- W2499579077 type Work @default.
- W2499579077 sameAs 2499579077 @default.
- W2499579077 citedByCount "0" @default.
- W2499579077 crossrefType "book-chapter" @default.
- W2499579077 hasAuthorship W2499579077A5014646926 @default.
- W2499579077 hasAuthorship W2499579077A5055508729 @default.
- W2499579077 hasConcept C118552586 @default.
- W2499579077 hasConcept C142724271 @default.
- W2499579077 hasConcept C148482608 @default.
- W2499579077 hasConcept C177713679 @default.
- W2499579077 hasConcept C1862650 @default.
- W2499579077 hasConcept C2779134260 @default.
- W2499579077 hasConcept C2780665704 @default.
- W2499579077 hasConcept C535046627 @default.
- W2499579077 hasConcept C71924100 @default.
- W2499579077 hasConcept C99508421 @default.
- W2499579077 hasConceptScore W2499579077C118552586 @default.
- W2499579077 hasConceptScore W2499579077C142724271 @default.
- W2499579077 hasConceptScore W2499579077C148482608 @default.
- W2499579077 hasConceptScore W2499579077C177713679 @default.
- W2499579077 hasConceptScore W2499579077C1862650 @default.
- W2499579077 hasConceptScore W2499579077C2779134260 @default.
- W2499579077 hasConceptScore W2499579077C2780665704 @default.
- W2499579077 hasConceptScore W2499579077C535046627 @default.
- W2499579077 hasConceptScore W2499579077C71924100 @default.
- W2499579077 hasConceptScore W2499579077C99508421 @default.
- W2499579077 hasLocation W24995790771 @default.
- W2499579077 hasOpenAccess W2499579077 @default.
- W2499579077 hasPrimaryLocation W24995790771 @default.
- W2499579077 hasRelatedWork W119908120 @default.
- W2499579077 hasRelatedWork W1589636036 @default.
- W2499579077 hasRelatedWork W1665144667 @default.
- W2499579077 hasRelatedWork W2017395943 @default.
- W2499579077 hasRelatedWork W2031644015 @default.
- W2499579077 hasRelatedWork W2034598007 @default.
- W2499579077 hasRelatedWork W2037252461 @default.
- W2499579077 hasRelatedWork W2056943618 @default.
- W2499579077 hasRelatedWork W2087366329 @default.
- W2499579077 hasRelatedWork W2114150655 @default.
- W2499579077 hasRelatedWork W2499956230 @default.
- W2499579077 hasRelatedWork W2800384130 @default.
- W2499579077 hasRelatedWork W2809406588 @default.
- W2499579077 hasRelatedWork W2886516234 @default.
- W2499579077 hasRelatedWork W2889781626 @default.
- W2499579077 hasRelatedWork W2970689169 @default.
- W2499579077 hasRelatedWork W2989617371 @default.
- W2499579077 hasRelatedWork W3210399433 @default.
- W2499579077 hasRelatedWork W989679070 @default.
- W2499579077 hasRelatedWork W2334974833 @default.
- W2499579077 isParatext "false" @default.
- W2499579077 isRetracted "false" @default.
- W2499579077 magId "2499579077" @default.
- W2499579077 workType "book-chapter" @default.