FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2499595666> ?p ?o ?g. }

• W2499595666 endingPage "8" @default.
• W2499595666 startingPage "1" @default.
• W2499595666 abstract "Microfluidic flow-focusing devices (FFD) are widely used to generate monodisperse droplets and microgels with controllable size, shape and composition for various biomedical applications. However, highly inconsistent and often low viability of cells encapsulated within the microgels prepared via microfluidic FFD has been a major concern, and yet this aspect has not been systematically explored. In this study, we demonstrate that the biocompatibility of microfluidic FFD to fabricate cell-laden microgels can be significantly enhanced by controlling the channel geometry. When a single emulsion (single) microfluidic FFD is used to fabricate cell-laden microgels, there is a significant decrease and batch-to-batch variability in the cell viability, regardless of their size and composition. It is determined that during droplet generation, some of the cells are exposed to the oil phase which is shown to have a cytotoxic effect. Therefore, a microfluidic device with a sequential ('double') flow-focusing channels is employed instead, in which a secondary aqueous phase containing cells enters the primary aqueous phase, so the cells' exposure to the oil phase is minimized by directing them to the center of droplets. This microfluidic channel geometry significantly enhances the biocompatibility of cell-laden microgels, while maintaining the benefits of a typical microfluidic process. This study therefore provides a simple and yet highly effective strategy to improve the biocompatibility of microfluidic fabrication of cell-laden microgels." @default.
• W2499595666 created "2016-08-23" @default.
• W2499595666 creator A5001879079 @default.
• W2499595666 creator A5082253993 @default.
• W2499595666 creator A5084215891 @default.
• W2499595666 date "2016-11-01" @default.
• W2499595666 modified "2023-09-24" @default.
• W2499595666 title "Enhancing the biocompatibility of microfluidics-assisted fabrication of cell-laden microgels with channel geometry" @default.
• W2499595666 cites W1966231948 @default.
• W2499595666 cites W1966288407 @default.
• W2499595666 cites W1969604041 @default.
• W2499595666 cites W1976842528 @default.
• W2499595666 cites W1978095627 @default.
• W2499595666 cites W1984853856 @default.
• W2499595666 cites W1988448600 @default.
• W2499595666 cites W1998266273 @default.
• W2499595666 cites W2002503549 @default.
• W2499595666 cites W2007944348 @default.
• W2499595666 cites W2008380896 @default.
• W2499595666 cites W2010130647 @default.
• W2499595666 cites W2012279125 @default.
• W2499595666 cites W2015067611 @default.
• W2499595666 cites W2019408568 @default.
• W2499595666 cites W2025931589 @default.
• W2499595666 cites W2028253963 @default.
• W2499595666 cites W2037710572 @default.
• W2499595666 cites W2040784316 @default.
• W2499595666 cites W2041033892 @default.
• W2499595666 cites W2050111018 @default.
• W2499595666 cites W2051998033 @default.
• W2499595666 cites W2053787721 @default.
• W2499595666 cites W2057410741 @default.
• W2499595666 cites W2061952589 @default.
• W2499595666 cites W2065511916 @default.
• W2499595666 cites W2065589119 @default.
• W2499595666 cites W2068547526 @default.
• W2499595666 cites W2070220795 @default.
• W2499595666 cites W2070957566 @default.
• W2499595666 cites W2073528628 @default.
• W2499595666 cites W2091903732 @default.
• W2499595666 cites W2092535047 @default.
• W2499595666 cites W2093846636 @default.
• W2499595666 cites W2104431913 @default.
• W2499595666 cites W2114953020 @default.
• W2499595666 cites W2115566578 @default.
• W2499595666 cites W2116764640 @default.
• W2499595666 cites W2121695733 @default.
• W2499595666 cites W2131067557 @default.
• W2499595666 cites W2137413193 @default.
• W2499595666 cites W2141055446 @default.
• W2499595666 cites W2145728691 @default.
• W2499595666 cites W2146956148 @default.
• W2499595666 cites W2154018518 @default.
• W2499595666 cites W2168115220 @default.
• W2499595666 cites W2170534668 @default.
• W2499595666 cites W2285676653 @default.
• W2499595666 cites W2316428117 @default.
• W2499595666 cites W4213261135 @default.
• W2499595666 doi "https://doi.org/10.1016/j.colsurfb.2016.07.041" @default.
• W2499595666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27478957" @default.
• W2499595666 hasPublicationYear "2016" @default.
• W2499595666 type Work @default.
• W2499595666 sameAs 2499595666 @default.
• W2499595666 citedByCount "22" @default.
• W2499595666 countsByYear W24995956662017 @default.
• W2499595666 countsByYear W24995956662018 @default.
• W2499595666 countsByYear W24995956662019 @default.
• W2499595666 countsByYear W24995956662020 @default.
• W2499595666 countsByYear W24995956662022 @default.
• W2499595666 countsByYear W24995956662023 @default.
• W2499595666 crossrefType "journal-article" @default.
• W2499595666 hasAuthorship W2499595666A5001879079 @default.
• W2499595666 hasAuthorship W2499595666A5082253993 @default.
• W2499595666 hasAuthorship W2499595666A5084215891 @default.
• W2499595666 hasConcept C11432220 @default.
• W2499595666 hasConcept C136525101 @default.
• W2499595666 hasConcept C142724271 @default.
• W2499595666 hasConcept C171250308 @default.
• W2499595666 hasConcept C178790620 @default.
• W2499595666 hasConcept C185592680 @default.
• W2499595666 hasConcept C188027245 @default.
• W2499595666 hasConcept C191897082 @default.
• W2499595666 hasConcept C192562407 @default.
• W2499595666 hasConcept C204787440 @default.
• W2499595666 hasConcept C2777230088 @default.
• W2499595666 hasConcept C2778123984 @default.
• W2499595666 hasConcept C71924100 @default.
• W2499595666 hasConcept C8673954 @default.
• W2499595666 hasConceptScore W2499595666C11432220 @default.
• W2499595666 hasConceptScore W2499595666C136525101 @default.
• W2499595666 hasConceptScore W2499595666C142724271 @default.
• W2499595666 hasConceptScore W2499595666C171250308 @default.
• W2499595666 hasConceptScore W2499595666C178790620 @default.
• W2499595666 hasConceptScore W2499595666C185592680 @default.
• W2499595666 hasConceptScore W2499595666C188027245 @default.
• W2499595666 hasConceptScore W2499595666C191897082 @default.
• W2499595666 hasConceptScore W2499595666C192562407 @default.
• W2499595666 hasConceptScore W2499595666C204787440 @default.

• next