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- W2499654543 abstract "Publisher Summary This chapter discusses cancer cell properties. The chapter discusses several related concepts, including genome stability, cell adhesion and motility, and apoptosis. Proteins that regulate the cell cycle have been identified by studying inherited diseases that predispose to cancer and by genetic analyses of different tumor types. The life of a growing cell is cyclical in nature, which has four major phases during which specific cellular functions are performed—S-phase, M-phase, G 1 -phase, and G 2 -phase. The mutation rate of tumor cells must exceed that of normal cells and that tumors might require early mutational events that not only confer a growth advantage to the cell, but also lead to an increase in genomic instability. Cells metastasize to new sites through subsequent changes in the expression of proteins that regulate cell adhesion and motility. Adhesion between identical molecules is known as homophilic adhesion, whereas adhesion between distinct molecules is termed heterophilic adhesion. The combined effects of cellular adhesion, motility, and protease secretion must be considered when studying tumor progression and metastasis. Apoptosis is a tightly regulated process of cell death necessary for proper development and cell turnover and occurs in all multicellular organisms, its timing and specificity essential to both normal development and maintenance of tissue function. Apoptosis is biochemically and morphologically distinct from necrosis or cell death because of tissue injury. Comparative studies of normal and transformed cells have identified many of the proteins and processes that maintain the normal physiology of the cell. In conclusion, this information will lead to new therapies that can modulate the systems that are disrupted in tumors." @default.
- W2499654543 created "2016-08-23" @default.
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- W2499654543 date "2001-01-01" @default.
- W2499654543 modified "2023-09-23" @default.
- W2499654543 title "Cancer Cell Properties" @default.
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- W2499654543 doi "https://doi.org/10.1016/b978-012656976-6/50159-1" @default.
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