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- W2499666811 abstract "Publisher Summary Health impairments can be observed following undue absorption of inorganic arsenic (Asi), which mainly occurs through inhalation in occupational settings or ingestion in the general population. Assessment of exposure based on the determination of the external dose often lacks precision due to variations in chemical species involved, in concentrations or due to varying toxicokinetic parameters. Therefore, on the basis of As metabolism data, the following biomarkers of internal exposure are generally proposed: the urinary excretion of the element and its concentration in hair and nails. This chapter has as its main purpose the review of recent studies of the relationship between external and internal As doses to assess their consistency among investigators. To avoid difficulties from possibly poor analytical techniques only literature published during the last two decades is considered. Despite some encouraging reports, the value of As levels in hair and nails as indices of internal exposure appears limited and efforts are needed to develop a standardized procedure to solve the problem of external contamination of samples. The agreement on the relationship between airborne As concentration and urinary excretion appears better. The level of As urinary excretion (seafood excluded) as a function of As oral intake through drinking water in steady state conditions has been reported by several authors from different countries. Despite possible ethnic and environmental differences, reported results display a quite satisfactory consistency." @default.
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- W2499666811 date "1999-01-01" @default.
- W2499666811 modified "2023-09-26" @default.
- W2499666811 title "Consistency of Biomarkers of Exposure to Inorganic Arsenic" @default.
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- W2499666811 doi "https://doi.org/10.1016/b978-008043648-7/50006-6" @default.
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