FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2499672655> ?p ?o ?g. }

• W2499672655 abstract "Background: Altered myocardial sympathetic innervation activity (AMSI) is known to be present in systolic heart failure patients (SHF) and recently SPECT imaging using I-123 mIBG heart to mediastinum (H/M) ratio <1.6 has been shown to predict MACE in the ADMIRE-HF trial. Left ventricular mechanical dyssynchrony (LVMD) is known to be present in a substantial number of SHF patients and has been studied mainly to guide CRT therapy. Recently gated SPECT has shown promise to provide an accurate assessment of LVMD. It remains unclear how the combination of AMSI and LVMD collectively affect clinical outcomes and other cardiovascular parameters. Objectives: The objectives are to examine the clinical characteristics and incremental prognostic value for MACE of LVMD determined by SPECT in SHF patients with or without abnormal cardiac MIBG uptake (H/M ratio < 1.6). Methods: Out of 30 SHF patients who participated from our institution in the ADMIRE-HF trial studying MIBG based AMSI, we included 22 patients with abnormal MIBG H/M ratio of <1.6. We performed gated SPECT LVMD analysis on these patients using the Emory Cardiac Toolbox. The 2 SPECT variables for LVMD assessed were histogram bandwidth and phase standard deviation both of which assess the extent of dispersion of LV activation during contraction as a marker of LVMD. Patients were followed up for a mean period of 6 years. The primary end point was mortality from any cause and secondary end point was heart failure admission or myocardial infarction or ICD shock. Results: 2 Groups were defined: Group A: n = 17 with H/M MIBG ratio < 1.6 and +LVMD and Group B, n = 5 H/M MIBG ratio < 1.6 and −LVMD. Baseline characteristics, cardiac risk factors and medications were comparable between both groups. LVEF was lower and RBBB was less common in Group A. There was no statistical difference in achievement of primary or secondary end points in the two groups including death heart failure readmissions, ICD shocks or MI. Conclusions: In our pilot study, we did not find definitive value of adding SPECT based LVMD to abnormal cardiac MIBG imaging in SHF patients with regards to predicting outcomes. Although our sample size is too small to make any definitive conclusions, it is possible that LVMD works independently through different pathways in the progression of SHF and hence may not necessarily add incremental value to AMSI determination using MIBG." @default.
• W2499672655 created "2016-08-23" @default.
• W2499672655 creator A5007420000 @default.
• W2499672655 creator A5019926579 @default.
• W2499672655 creator A5073689812 @default.
• W2499672655 date "2016-01-01" @default.
• W2499672655 modified "2023-09-30" @default.
• W2499672655 title "Is There an Incremental Prognostic Value of Evaluating Left Ventricular Dyssynchrony by Gated SPECT in Patients with Systolic Heart Failure and Altered Myocardial Sympathetic Innervation as Evaluated by Cardiac I-123 mIBG Imaging?" @default.
• W2499672655 cites W1564833283 @default.
• W2499672655 cites W1930119086 @default.
• W2499672655 cites W1975907671 @default.
• W2499672655 cites W2006127589 @default.
• W2499672655 cites W2021535320 @default.
• W2499672655 cites W2050633524 @default.
• W2499672655 cites W2062760666 @default.
• W2499672655 cites W2067348448 @default.
• W2499672655 cites W2074429652 @default.
• W2499672655 cites W2094065595 @default.
• W2499672655 cites W2094543265 @default.
• W2499672655 cites W2108918478 @default.
• W2499672655 cites W2110740991 @default.
• W2499672655 cites W2134538426 @default.
• W2499672655 cites W2215396592 @default.
• W2499672655 cites W2414890241 @default.
• W2499672655 cites W2047198412 @default.
• W2499672655 doi "https://doi.org/10.4236/wjnst.2016.63018" @default.
• W2499672655 hasPublicationYear "2016" @default.
• W2499672655 type Work @default.
• W2499672655 sameAs 2499672655 @default.
• W2499672655 citedByCount "0" @default.
• W2499672655 crossrefType "journal-article" @default.
• W2499672655 hasAuthorship W2499672655A5007420000 @default.
• W2499672655 hasAuthorship W2499672655A5019926579 @default.
• W2499672655 hasAuthorship W2499672655A5073689812 @default.
• W2499672655 hasBestOaLocation W24996726551 @default.
• W2499672655 hasConcept C126322002 @default.
• W2499672655 hasConcept C164705383 @default.
• W2499672655 hasConcept C203092338 @default.
• W2499672655 hasConcept C2776034619 @default.
• W2499672655 hasConcept C2776720267 @default.
• W2499672655 hasConcept C2776902491 @default.
• W2499672655 hasConcept C2778198053 @default.
• W2499672655 hasConcept C2778213512 @default.
• W2499672655 hasConcept C2778405248 @default.
• W2499672655 hasConcept C2780400711 @default.
• W2499672655 hasConcept C2780739214 @default.
• W2499672655 hasConcept C500558357 @default.
• W2499672655 hasConcept C535046627 @default.
• W2499672655 hasConcept C71924100 @default.
• W2499672655 hasConcept C78085059 @default.
• W2499672655 hasConceptScore W2499672655C126322002 @default.
• W2499672655 hasConceptScore W2499672655C164705383 @default.
• W2499672655 hasConceptScore W2499672655C203092338 @default.
• W2499672655 hasConceptScore W2499672655C2776034619 @default.
• W2499672655 hasConceptScore W2499672655C2776720267 @default.
• W2499672655 hasConceptScore W2499672655C2776902491 @default.
• W2499672655 hasConceptScore W2499672655C2778198053 @default.
• W2499672655 hasConceptScore W2499672655C2778213512 @default.
• W2499672655 hasConceptScore W2499672655C2778405248 @default.
• W2499672655 hasConceptScore W2499672655C2780400711 @default.
• W2499672655 hasConceptScore W2499672655C2780739214 @default.
• W2499672655 hasConceptScore W2499672655C500558357 @default.
• W2499672655 hasConceptScore W2499672655C535046627 @default.
• W2499672655 hasConceptScore W2499672655C71924100 @default.
• W2499672655 hasConceptScore W2499672655C78085059 @default.
• W2499672655 hasLocation W24996726551 @default.
• W2499672655 hasOpenAccess W2499672655 @default.
• W2499672655 hasPrimaryLocation W24996726551 @default.
• W2499672655 hasRelatedWork W1962733462 @default.
• W2499672655 hasRelatedWork W2020697799 @default.
• W2499672655 hasRelatedWork W2066356851 @default.
• W2499672655 hasRelatedWork W2265188873 @default.
• W2499672655 hasRelatedWork W2396878532 @default.
• W2499672655 hasRelatedWork W2606998104 @default.
• W2499672655 hasRelatedWork W2809590746 @default.
• W2499672655 hasRelatedWork W2905250463 @default.
• W2499672655 hasRelatedWork W2944497468 @default.
• W2499672655 hasRelatedWork W3009834372 @default.
• W2499672655 hasRelatedWork W3081434528 @default.
• W2499672655 hasRelatedWork W3082379387 @default.
• W2499672655 hasRelatedWork W3092064297 @default.
• W2499672655 hasRelatedWork W3093952888 @default.
• W2499672655 hasRelatedWork W3118624033 @default.
• W2499672655 hasRelatedWork W3164558271 @default.
• W2499672655 hasRelatedWork W3205314689 @default.
• W2499672655 hasRelatedWork W780365125 @default.
• W2499672655 hasRelatedWork W958118954 @default.
• W2499672655 hasRelatedWork W2078362518 @default.
• W2499672655 isParatext "false" @default.
• W2499672655 isRetracted "false" @default.
• W2499672655 magId "2499672655" @default.
• W2499672655 workType "article" @default.