Matches in SemOpenAlex for { <https://semopenalex.org/work/W2499679957> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2499679957 abstract "Abstract Human epidermal growth factor receptor 2 (HER2)-targeted agents are an effective approach to treating HER2-positive breast cancer patients. However, the lack of survival benefit in HER2-negative patients as well as the toxic effects and high cost of the drugs highlight the need for accurate and prompt assessment of HER2 status. Our aim was to evaluate the clinical utility of a novel rapid dual in-situ hybridization (RISH) method developed to facilitate hybridization. The method takes advantage of the non-contact mixing effect of an alternating current (AC) electric field. One hundred sixty-three specimens were used from patients diagnosed with primary breast cancers identified immunohistochemically as HER2 0/1(+), (2+) or (3+). The specimens were all tested using conventional dual in-situ hybridization (DISH), DISH with an automated slide stainer, and RISH. With RISH the HER2 test was completed within 6 h, as compared to 20–22 h needed for the standard protocol. Although RISH produced results more promptly using smaller amounts of labeled antibody, the staining and accuracy of HER2 status evaluation with RISH was equal to or greater than with DISH. These results suggest RISH could be used as a clinical tool to promptly determine HER2 status." @default.
- W2499679957 created "2016-08-23" @default.
- W2499679957 creator A5003732827 @default.
- W2499679957 creator A5050961403 @default.
- W2499679957 creator A5051197611 @default.
- W2499679957 creator A5055719008 @default.
- W2499679957 creator A5065427876 @default.
- W2499679957 creator A5068074868 @default.
- W2499679957 creator A5072672282 @default.
- W2499679957 creator A5089412167 @default.
- W2499679957 date "2016-07-22" @default.
- W2499679957 modified "2023-09-27" @default.
- W2499679957 title "Novel method for rapid in-situ hybridization of HER2 using non-contact alternating-current electric-field mixing" @default.
- W2499679957 cites W1773887946 @default.
- W2499679957 cites W1994135074 @default.
- W2499679957 cites W2009059630 @default.
- W2499679957 cites W2023009798 @default.
- W2499679957 cites W2030638637 @default.
- W2499679957 cites W2032733397 @default.
- W2499679957 cites W2039194640 @default.
- W2499679957 cites W2041431825 @default.
- W2499679957 cites W2042806530 @default.
- W2499679957 cites W2058032190 @default.
- W2499679957 cites W2067287567 @default.
- W2499679957 cites W2101979288 @default.
- W2499679957 cites W2110444464 @default.
- W2499679957 cites W2120661754 @default.
- W2499679957 cites W2129363225 @default.
- W2499679957 cites W2141546964 @default.
- W2499679957 cites W2156677665 @default.
- W2499679957 cites W2159967578 @default.
- W2499679957 cites W2160333568 @default.
- W2499679957 cites W2166199281 @default.
- W2499679957 doi "https://doi.org/10.1038/srep30034" @default.
- W2499679957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4957099" @default.
- W2499679957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27443187" @default.
- W2499679957 hasPublicationYear "2016" @default.
- W2499679957 type Work @default.
- W2499679957 sameAs 2499679957 @default.
- W2499679957 citedByCount "9" @default.
- W2499679957 countsByYear W24996799572017 @default.
- W2499679957 countsByYear W24996799572018 @default.
- W2499679957 countsByYear W24996799572019 @default.
- W2499679957 countsByYear W24996799572020 @default.
- W2499679957 countsByYear W24996799572022 @default.
- W2499679957 crossrefType "journal-article" @default.
- W2499679957 hasAuthorship W2499679957A5003732827 @default.
- W2499679957 hasAuthorship W2499679957A5050961403 @default.
- W2499679957 hasAuthorship W2499679957A5051197611 @default.
- W2499679957 hasAuthorship W2499679957A5055719008 @default.
- W2499679957 hasAuthorship W2499679957A5065427876 @default.
- W2499679957 hasAuthorship W2499679957A5068074868 @default.
- W2499679957 hasAuthorship W2499679957A5072672282 @default.
- W2499679957 hasAuthorship W2499679957A5089412167 @default.
- W2499679957 hasBestOaLocation W24996799571 @default.
- W2499679957 hasConcept C104317684 @default.
- W2499679957 hasConcept C121608353 @default.
- W2499679957 hasConcept C126322002 @default.
- W2499679957 hasConcept C136229726 @default.
- W2499679957 hasConcept C150194340 @default.
- W2499679957 hasConcept C192562407 @default.
- W2499679957 hasConcept C530470458 @default.
- W2499679957 hasConcept C55493867 @default.
- W2499679957 hasConcept C71924100 @default.
- W2499679957 hasConcept C81439078 @default.
- W2499679957 hasConcept C86803240 @default.
- W2499679957 hasConceptScore W2499679957C104317684 @default.
- W2499679957 hasConceptScore W2499679957C121608353 @default.
- W2499679957 hasConceptScore W2499679957C126322002 @default.
- W2499679957 hasConceptScore W2499679957C136229726 @default.
- W2499679957 hasConceptScore W2499679957C150194340 @default.
- W2499679957 hasConceptScore W2499679957C192562407 @default.
- W2499679957 hasConceptScore W2499679957C530470458 @default.
- W2499679957 hasConceptScore W2499679957C55493867 @default.
- W2499679957 hasConceptScore W2499679957C71924100 @default.
- W2499679957 hasConceptScore W2499679957C81439078 @default.
- W2499679957 hasConceptScore W2499679957C86803240 @default.
- W2499679957 hasIssue "1" @default.
- W2499679957 hasLocation W24996799571 @default.
- W2499679957 hasLocation W24996799572 @default.
- W2499679957 hasLocation W24996799573 @default.
- W2499679957 hasLocation W24996799574 @default.
- W2499679957 hasOpenAccess W2499679957 @default.
- W2499679957 hasPrimaryLocation W24996799571 @default.
- W2499679957 hasRelatedWork W1431904956 @default.
- W2499679957 hasRelatedWork W2018879842 @default.
- W2499679957 hasRelatedWork W2737498735 @default.
- W2499679957 hasRelatedWork W2744391499 @default.
- W2499679957 hasRelatedWork W2898370298 @default.
- W2499679957 hasRelatedWork W2899084033 @default.
- W2499679957 hasRelatedWork W3041790586 @default.
- W2499679957 hasRelatedWork W3120461830 @default.
- W2499679957 hasRelatedWork W3144504424 @default.
- W2499679957 hasRelatedWork W4292492973 @default.
- W2499679957 hasVolume "6" @default.
- W2499679957 isParatext "false" @default.
- W2499679957 isRetracted "false" @default.
- W2499679957 magId "2499679957" @default.
- W2499679957 workType "article" @default.