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- W2499687690 abstract "In eukaryotic cells the genome is highly spatially organized. Functional relevance of higher order genome organization is implied by the fact that specific genes, and even whole chromosomes, alter spatial position in concert with functional changes within the nucleus, for example with modifications to chromatin or transcription. The exact molecular pathways that regulate spatial genome organization and the full implication to the cell of such an organization remain to be determined. However, there is a growing realization that the spatial organization of the genome can be used as a marker of disease. While global genome organization patterns remain largely conserved in disease, some genes and chromosomes occupy distinct nuclear positions in diseased cells compared to their normal counterparts, with the patterns of reorganization differing between diseases. Importantly, mapping the spatial positioning patterns of specific genomic loci can distinguish cancerous tissue from benign with high accuracy. Genome positioning is an attractive novel biomarker since additional quantitative biomarkers are urgently required in many cancer types. Current diagnostic techniques are often subjective and generally lack the ability to identify aggressive cancer from indolent, which can lead to over- or under-treatment of patients. Proof-of-principle for the use of genome positioning as a diagnostic tool has been provided based on small scale retrospective studies. Future large-scale studies are required to assess the feasibility of bringing spatial genome organization-based diagnostics to the clinical setting and to determine if the positioning patterns of specific loci can be useful biomarkers for cancer prognosis. Since spatial reorganization of the genome has been identified in multiple human diseases, it is likely that spatial genome positioning patterns as a diagnostic biomarker may be applied to many diseases." @default.
- W2499687690 created "2016-08-23" @default.
- W2499687690 creator A5033068859 @default.
- W2499687690 date "2016-07-26" @default.
- W2499687690 modified "2023-10-18" @default.
- W2499687690 title "Spatial Genome Organization and Its Emerging Role as a Potential Diagnosis Tool" @default.
- W2499687690 cites W143183448 @default.
- W2499687690 cites W1541013519 @default.
- W2499687690 cites W1553065669 @default.
- W2499687690 cites W1603862075 @default.
- W2499687690 cites W1859117663 @default.
- W2499687690 cites W1887325245 @default.
- W2499687690 cites W1889137377 @default.
- W2499687690 cites W1925466126 @default.
- W2499687690 cites W1949649529 @default.
- W2499687690 cites W1951209160 @default.
- W2499687690 cites W1965637104 @default.
- W2499687690 cites W1967186439 @default.
- W2499687690 cites W1968127700 @default.
- W2499687690 cites W1968554285 @default.
- W2499687690 cites W1970338621 @default.
- W2499687690 cites W1970640134 @default.
- W2499687690 cites W1971969854 @default.
- W2499687690 cites W1972132227 @default.
- W2499687690 cites W1972997931 @default.
- W2499687690 cites W1973062929 @default.
- W2499687690 cites W1975542854 @default.
- W2499687690 cites W1976060096 @default.
- W2499687690 cites W1977339483 @default.
- W2499687690 cites W1978992677 @default.
- W2499687690 cites W1979705716 @default.
- W2499687690 cites W1980023815 @default.
- W2499687690 cites W1982295124 @default.
- W2499687690 cites W1983533553 @default.
- W2499687690 cites W1984304535 @default.
- W2499687690 cites W1984340155 @default.
- W2499687690 cites W1985422225 @default.
- W2499687690 cites W1986096983 @default.
- W2499687690 cites W1987760879 @default.
- W2499687690 cites W1988757730 @default.
- W2499687690 cites W1991149014 @default.
- W2499687690 cites W1993570130 @default.
- W2499687690 cites W1996125336 @default.
- W2499687690 cites W2001968322 @default.
- W2499687690 cites W2003250511 @default.
- W2499687690 cites W2003375936 @default.
- W2499687690 cites W2003500892 @default.
- W2499687690 cites W2003660636 @default.
- W2499687690 cites W2004268823 @default.
- W2499687690 cites W2005309418 @default.
- W2499687690 cites W2005944417 @default.
- W2499687690 cites W2007107824 @default.
- W2499687690 cites W2008667520 @default.
- W2499687690 cites W2009199987 @default.
- W2499687690 cites W2010399610 @default.
- W2499687690 cites W2011170131 @default.
- W2499687690 cites W2011430551 @default.
- W2499687690 cites W2015965026 @default.
- W2499687690 cites W2016656670 @default.
- W2499687690 cites W2018825948 @default.
- W2499687690 cites W2022156993 @default.
- W2499687690 cites W2022610139 @default.
- W2499687690 cites W2023186182 @default.
- W2499687690 cites W2025660464 @default.
- W2499687690 cites W2026180423 @default.
- W2499687690 cites W2026755238 @default.
- W2499687690 cites W2026865241 @default.
- W2499687690 cites W2026984588 @default.
- W2499687690 cites W2028702644 @default.
- W2499687690 cites W2029673502 @default.
- W2499687690 cites W2030948026 @default.
- W2499687690 cites W2032131359 @default.
- W2499687690 cites W2032840484 @default.
- W2499687690 cites W2033160626 @default.
- W2499687690 cites W2036565798 @default.
- W2499687690 cites W2038657480 @default.
- W2499687690 cites W2038774969 @default.
- W2499687690 cites W2040275880 @default.
- W2499687690 cites W2045974768 @default.
- W2499687690 cites W2050479831 @default.
- W2499687690 cites W2051518111 @default.
- W2499687690 cites W2051869287 @default.
- W2499687690 cites W2052586663 @default.
- W2499687690 cites W2055339846 @default.
- W2499687690 cites W2055977185 @default.
- W2499687690 cites W2056258039 @default.
- W2499687690 cites W2056458596 @default.
- W2499687690 cites W2056482755 @default.
- W2499687690 cites W2057341073 @default.
- W2499687690 cites W2058402081 @default.
- W2499687690 cites W2059764680 @default.
- W2499687690 cites W2060485452 @default.
- W2499687690 cites W2060862745 @default.
- W2499687690 cites W2067761440 @default.
- W2499687690 cites W2068906158 @default.
- W2499687690 cites W2069893981 @default.
- W2499687690 cites W2070021921 @default.
- W2499687690 cites W2071163737 @default.
- W2499687690 cites W2072975087 @default.
- W2499687690 cites W2073242373 @default.