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• W2499697692 abstract "We studied telomere length in 32 CML patients who discontinued imatinib after achieving complete molecular remission and 32 age-sex-matched controls. The relative telomere length (RTL) was determined by q-PCR as the telomere to single copy gene (36B4) ratio normalized to a reference sample (K-562 DNA). Age-corrected RTL (acRTL) was also obtained. The 36-month probability of treatment-free remission (TFR) was 59.4 %. TFR patients showed shorter acRTL compared to relapsed (mean ± SD = 0.01 ± 0.14 vs 0.20 ± 0.21; p = 0.01). TFR was significantly higher in CML patients with acRTL ≤0.09 (78.9 vs 30.8 %, p = 0.002). CML stem cells harboring longer telomeres possibly maintain a proliferative potential after treatment discontinuation." @default.
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• W2499697692 date "2016-07-29" @default.
• W2499697692 modified "2023-10-18" @default.
• W2499697692 title "Telomere length shortening is associated with treatment-free remission in chronic myeloid leukemia patients" @default.
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• W2499697692 doi "https://doi.org/10.1186/s13045-016-0293-y" @default.
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