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- W2499754927 abstract "Publisher Summary This chapter focuses on murine model of pneumonia using aerosol inoculation. In this model, any species or strain could be used and preliminary experiments should be performed to determine optimal bacterial inocula and treatment delay. No specialized housing or care is required and immunocompetent mice may be used after appropriate acclimatization. To render the mice neutropenic for 48 hours after infection, two doses of cyclophosphamide are injected intraperitoneally for four days (150 mg/kg) and one day (100 mg/kg) before the experiment. The duration of neutropenia may be prolonged by an additional 100 mg/kg intraperitoneal injection of cyclophosphamide every 48 hours. A diffuse pneumonia is induced by exposing the mice in a closed chamber for 45 minutes to a 4–5 l/minute rate of aerosol generated by a Collison nebulizer. The bacteria in the lung begin log phase growth in approximately 6–8 hours following infection. The mice become bacteremic approximately 14–16 hours later, when there is histologic evidence of bronchopneumonia. The infection is lethal in control mice within 36–48 hours. This pneumonia model can be used in survival studies looking at 50% protective doses or in studies quantifying bacterial inocula at various time points. To evaluate the antimicrobial activity at the end of 24 hours of therapy, the lung inocula in four mice are generally sacrificed and quantified for each specific antimicrobial regimen." @default.
- W2499754927 created "2016-08-23" @default.
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- W2499754927 date "1999-01-01" @default.
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- W2499754927 title "Murine Models of Pneumonia Using Aerosol Inoculation" @default.
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- W2499754927 doi "https://doi.org/10.1016/b978-012775390-4/50202-5" @default.
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