Matches in SemOpenAlex for { <https://semopenalex.org/work/W2499793886> ?p ?o ?g. }
- W2499793886 endingPage "138" @default.
- W2499793886 startingPage "79" @default.
- W2499793886 abstract "Bacterial mutation tests using various Salmonella typhimurium LT2 and Escherichia coli WP2 strains are by far the most widely used systems for predicting mutagenicity of chemicals and other materials including complex mixtures and environmental contaminants. The tests are generally required worldwide by regulatory authorities as an initial screen for potential long-term adverse health effects of new materials and chemicals, including drugs, agrochemicals, medical devices, and household agents. The initial sections of this chapter describe the theoretical background and the history of the test to allow a better understanding of the principles of its performance and interpretation. Rigorous standardized procedures necessary to perform tests suitable for screening and regulatory submission are presented that closely follow the recommendations of the developers of the test and regulatory guidelines and are based on the scientific community’s 40 years of experience with the test. All aspects of routine testing including bacterial strain purification, maintenance and characterization, use of S9 mix, concurrent controls, handling and interpretation of results, as well as clarification of unexpected findings or borderline results are covered. These procedures should give reproducible results in the shortest timeframe and minimize workload while avoiding problems, errors, and repeat testing. Variations of the test including screening versions used at an early stage of development, when test article supply and resources are limited, are discussed briefly." @default.
- W2499793886 created "2016-08-23" @default.
- W2499793886 creator A5002731694 @default.
- W2499793886 creator A5079179837 @default.
- W2499793886 creator A5085564507 @default.
- W2499793886 date "2016-01-01" @default.
- W2499793886 modified "2023-10-17" @default.
- W2499793886 title "The Bacterial Reverse Mutation Test" @default.
- W2499793886 cites W1495393562 @default.
- W2499793886 cites W1598828862 @default.
- W2499793886 cites W1950748857 @default.
- W2499793886 cites W1966000263 @default.
- W2499793886 cites W1969413381 @default.
- W2499793886 cites W1972292978 @default.
- W2499793886 cites W1973195696 @default.
- W2499793886 cites W1973879072 @default.
- W2499793886 cites W1974554220 @default.
- W2499793886 cites W1975756125 @default.
- W2499793886 cites W1976120765 @default.
- W2499793886 cites W1978945530 @default.
- W2499793886 cites W1979105963 @default.
- W2499793886 cites W1979180525 @default.
- W2499793886 cites W1983410267 @default.
- W2499793886 cites W1984466901 @default.
- W2499793886 cites W1986671347 @default.
- W2499793886 cites W1987923762 @default.
- W2499793886 cites W1998883821 @default.
- W2499793886 cites W1999828881 @default.
- W2499793886 cites W2002292710 @default.
- W2499793886 cites W2004678494 @default.
- W2499793886 cites W2005156172 @default.
- W2499793886 cites W2007259461 @default.
- W2499793886 cites W2008677397 @default.
- W2499793886 cites W2009922154 @default.
- W2499793886 cites W2017067698 @default.
- W2499793886 cites W2019345231 @default.
- W2499793886 cites W2025123753 @default.
- W2499793886 cites W2025817642 @default.
- W2499793886 cites W2025919994 @default.
- W2499793886 cites W2026357372 @default.
- W2499793886 cites W2034969136 @default.
- W2499793886 cites W2035759555 @default.
- W2499793886 cites W2037735263 @default.
- W2499793886 cites W2038514050 @default.
- W2499793886 cites W2043100189 @default.
- W2499793886 cites W2044198346 @default.
- W2499793886 cites W2044566026 @default.
- W2499793886 cites W2045873169 @default.
- W2499793886 cites W2047723562 @default.
- W2499793886 cites W2049350359 @default.
- W2499793886 cites W2053855895 @default.
- W2499793886 cites W2054229424 @default.
- W2499793886 cites W2055353720 @default.
- W2499793886 cites W2055602480 @default.
- W2499793886 cites W2056676587 @default.
- W2499793886 cites W2060222479 @default.
- W2499793886 cites W2061001060 @default.
- W2499793886 cites W2062206346 @default.
- W2499793886 cites W2063097997 @default.
- W2499793886 cites W2063754054 @default.
- W2499793886 cites W2065835219 @default.
- W2499793886 cites W2065962952 @default.
- W2499793886 cites W2070672695 @default.
- W2499793886 cites W2087646741 @default.
- W2499793886 cites W2088373777 @default.
- W2499793886 cites W2096244703 @default.
- W2499793886 cites W2103503554 @default.
- W2499793886 cites W2103656287 @default.
- W2499793886 cites W2107480572 @default.
- W2499793886 cites W2112832820 @default.
- W2499793886 cites W2124810634 @default.
- W2499793886 cites W2131219875 @default.
- W2499793886 cites W2143654031 @default.
- W2499793886 cites W2147837969 @default.
- W2499793886 cites W2159082057 @default.
- W2499793886 cites W2321914463 @default.
- W2499793886 cites W2418522730 @default.
- W2499793886 cites W36978170 @default.
- W2499793886 cites W4256552746 @default.
- W2499793886 doi "https://doi.org/10.1016/b978-0-12-800764-8.00004-5" @default.
- W2499793886 hasPublicationYear "2016" @default.
- W2499793886 type Work @default.
- W2499793886 sameAs 2499793886 @default.
- W2499793886 citedByCount "25" @default.
- W2499793886 countsByYear W24997938862016 @default.
- W2499793886 countsByYear W24997938862018 @default.
- W2499793886 countsByYear W24997938862020 @default.
- W2499793886 countsByYear W24997938862021 @default.
- W2499793886 countsByYear W24997938862022 @default.
- W2499793886 countsByYear W24997938862023 @default.
- W2499793886 crossrefType "book-chapter" @default.
- W2499793886 hasAuthorship W2499793886A5002731694 @default.
- W2499793886 hasAuthorship W2499793886A5079179837 @default.
- W2499793886 hasAuthorship W2499793886A5085564507 @default.
- W2499793886 hasConcept C111919701 @default.
- W2499793886 hasConcept C112930515 @default.
- W2499793886 hasConcept C127413603 @default.
- W2499793886 hasConcept C151730666 @default.