FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2499804889> ?p ?o ?g. }

• W2499804889 abstract "Highly Ca2+ permeable receptor potential channel vanilloid type 6 (TRPV6) modulates a variety of biological functions including calcium-dependent cell growth and apoptosis. So far, the role of TRPV6 in controlling growth of pancreatic neuroendocrine tumour (NET) cells is unknown. In the present study, we characterize the expression of TRPV6 in pancreatic BON-1 and QGP-1 NET cells. Furthermore, we evaluate the impact of TRPV6 on intracellular calcium, the activity of nuclear factor of activated T-cells (NFAT) and proliferation of BON-1 cells. TRPV6 expression was assessed by real-time PCR and Western blot. TRPV6 mRNA expression and protein production were down-regulated by siRNA. Changes in intracellular calcium levels were detected by fluorescence calcium imaging (fura-2/AM). NFAT activity was studied by NFAT reporter assay; cell proliferation by bromodeoxyuridine (BrdU), MTT and propidium iodine staining. TRPV6 mRNA and protein are present in BON-1 and QGP-1 NET-cells. Down-regulation of TRPV6 attenuates BON-1 cell proliferation. TRPV6 down-regulation is associated with decreased Ca2+ response pattern and reduced NFAT activity. In conclusion, TRPV6 is expressed in pancreatic NETs and modulates cell proliferation via Ca2+-dependent mechanism, which is accompanied by NFAT activation." @default.
• W2499804889 created "2016-08-23" @default.
• W2499804889 creator A5042687109 @default.
• W2499804889 creator A5062063876 @default.
• W2499804889 creator A5065126821 @default.
• W2499804889 creator A5068093546 @default.
• W2499804889 creator A5086161688 @default.
• W2499804889 creator A5087160874 @default.
• W2499804889 date "2016-08-01" @default.
• W2499804889 modified "2023-10-17" @default.
• W2499804889 title "TRPV6 modulates proliferation of human pancreatic neuroendocrine BON-1 tumour cells" @default.
• W2499804889 cites W1590954867 @default.
• W2499804889 cites W1879722995 @default.
• W2499804889 cites W1965053941 @default.
• W2499804889 cites W1967156349 @default.
• W2499804889 cites W1969597161 @default.
• W2499804889 cites W1970210211 @default.
• W2499804889 cites W1974768397 @default.
• W2499804889 cites W1976791447 @default.
• W2499804889 cites W1984395022 @default.
• W2499804889 cites W1996024251 @default.
• W2499804889 cites W2002731368 @default.
• W2499804889 cites W2004466285 @default.
• W2499804889 cites W2021872682 @default.
• W2499804889 cites W2032148015 @default.
• W2499804889 cites W2045748219 @default.
• W2499804889 cites W2057821228 @default.
• W2499804889 cites W2066260339 @default.
• W2499804889 cites W2067649635 @default.
• W2499804889 cites W2071131691 @default.
• W2499804889 cites W2071964380 @default.
• W2499804889 cites W2073580835 @default.
• W2499804889 cites W2073895228 @default.
• W2499804889 cites W2080656009 @default.
• W2499804889 cites W2081266168 @default.
• W2499804889 cites W2081730365 @default.
• W2499804889 cites W2081765272 @default.
• W2499804889 cites W2087566535 @default.
• W2499804889 cites W2103356379 @default.
• W2499804889 cites W2107280045 @default.
• W2499804889 cites W2109353494 @default.
• W2499804889 cites W2116881836 @default.
• W2499804889 cites W2128783914 @default.
• W2499804889 cites W2129635168 @default.
• W2499804889 cites W2140707292 @default.
• W2499804889 cites W2141260882 @default.
• W2499804889 cites W2157109097 @default.
• W2499804889 cites W2169774852 @default.
• W2499804889 cites W2280796933 @default.
• W2499804889 cites W2414993363 @default.
• W2499804889 cites W4247965102 @default.
• W2499804889 doi "https://doi.org/10.1042/bsr20160106" @default.
• W2499804889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4995500" @default.
• W2499804889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27450545" @default.
• W2499804889 hasPublicationYear "2016" @default.
• W2499804889 type Work @default.
• W2499804889 sameAs 2499804889 @default.
• W2499804889 citedByCount "9" @default.
• W2499804889 countsByYear W24998048892017 @default.
• W2499804889 countsByYear W24998048892019 @default.
• W2499804889 countsByYear W24998048892020 @default.
• W2499804889 countsByYear W24998048892021 @default.
• W2499804889 countsByYear W24998048892022 @default.
• W2499804889 countsByYear W24998048892023 @default.
• W2499804889 crossrefType "journal-article" @default.
• W2499804889 hasAuthorship W2499804889A5042687109 @default.
• W2499804889 hasAuthorship W2499804889A5062063876 @default.
• W2499804889 hasAuthorship W2499804889A5065126821 @default.
• W2499804889 hasAuthorship W2499804889A5068093546 @default.
• W2499804889 hasAuthorship W2499804889A5086161688 @default.
• W2499804889 hasAuthorship W2499804889A5087160874 @default.
• W2499804889 hasBestOaLocation W24998048891 @default.
• W2499804889 hasConcept C104317684 @default.
• W2499804889 hasConcept C153911025 @default.
• W2499804889 hasConcept C155520015 @default.
• W2499804889 hasConcept C178790620 @default.
• W2499804889 hasConcept C185592680 @default.
• W2499804889 hasConcept C189938988 @default.
• W2499804889 hasConcept C519063684 @default.
• W2499804889 hasConcept C55493867 @default.
• W2499804889 hasConcept C62112901 @default.
• W2499804889 hasConcept C86339819 @default.
• W2499804889 hasConcept C86803240 @default.
• W2499804889 hasConcept C87975464 @default.
• W2499804889 hasConcept C95444343 @default.
• W2499804889 hasConceptScore W2499804889C104317684 @default.
• W2499804889 hasConceptScore W2499804889C153911025 @default.
• W2499804889 hasConceptScore W2499804889C155520015 @default.
• W2499804889 hasConceptScore W2499804889C178790620 @default.
• W2499804889 hasConceptScore W2499804889C185592680 @default.
• W2499804889 hasConceptScore W2499804889C189938988 @default.
• W2499804889 hasConceptScore W2499804889C519063684 @default.
• W2499804889 hasConceptScore W2499804889C55493867 @default.
• W2499804889 hasConceptScore W2499804889C62112901 @default.
• W2499804889 hasConceptScore W2499804889C86339819 @default.
• W2499804889 hasConceptScore W2499804889C86803240 @default.
• W2499804889 hasConceptScore W2499804889C87975464 @default.
• W2499804889 hasConceptScore W2499804889C95444343 @default.
• W2499804889 hasIssue "4" @default.
• W2499804889 hasLocation W24998048891 @default.

• next