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• W2499896871 endingPage "1116" @default.
• W2499896871 startingPage "1103" @default.
• W2499896871 abstract "LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase activity and has since been shown to have multiple essential roles in mammalian biology. Given its enzymatic activity and its high-level expression in many human malignancies, a significant recent focus has been the development of pharmacologic inhibitors. Here we summarize structural and biochemical knowledge of this important epigenetic regulator, with a particular emphasis on the functional and preclinical studies in oncology that have provided justification for the evaluation of tranylcypromine derivative LSD1 inhibitors in early phase clinical trials." @default.
• W2499896871 created "2016-08-23" @default.
• W2499896871 creator A5064845209 @default.
• W2499896871 creator A5088625776 @default.
• W2499896871 date "2016-08-01" @default.
• W2499896871 modified "2023-10-12" @default.
• W2499896871 title "LSD1: biologic roles and therapeutic targeting" @default.
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