FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2499951825> ?p ?o ?g. }

• W2499951825 endingPage "373" @default.
• W2499951825 startingPage "358" @default.
• W2499951825 abstract "Purpose Prolactinoma (prolactin-secreting pituitary adenoma) is one of the most common estrogen-related functional pituitary tumors. As an agonist of the dopamine D2 receptor, bromocriptine is used widely to inhibit prolactinoma progression. On the other hand, it is not always effective in clinical application. Although a dopamine D2 receptor deficiency contributes to the impaired efficiency of bromocriptine therapy to some extent, it is unknown whether there some other underlying mechanisms leading to bromocriptine resistance in prolactinoma treatment. That is the main point addressed in this project. Materials and Methods Human prolactinoma samples were used to analyze the S-phase kinase associated protein 2 (SKP2) expression level. Nutlin-3/adriamycin/cisplatin-treated GH3 and MMQ cells were used to analyze apoptosis in SKP2 overexpression or knockdown cells. SKP2 expression and the interaction partners of SKP2 were also detected after a bromocriptine treatment in 293T. Apoptosis was analyzed in C25 and bromocriptine-treated GH3 cells. Results Compared to normal pituitary samples, most prolactinoma samples exhibit higher levels of SKP2 expression, which could inhibit apoptosis in a p53-dependent manner. In addition, the bromocriptine treatment prolonged the half-life of SKP2 and resulted in SKP2 overexpression to a greater extent, which in turn compromised its pro-apoptotic effect. As a result, the bromocriptine treatment combined with C25 (a SKP2 inhibitor) led to the maximal apoptosis of human prolactinoma cells. Conclusion These findings indicated that SKP2 inhibition sensitized the prolactinoma cells to bromocriptine and helped promote apoptosis. Moreover, a combined treatment of bromocriptine and C25 may contribute to the maximal apoptosis of human prolactinoma cells. Key words: Apoptosis, Bromocriptine, Prolactinoma, SKP2, C25" @default.
• W2499951825 created "2016-08-23" @default.
• W2499951825 creator A5003753493 @default.
• W2499951825 creator A5008623292 @default.
• W2499951825 creator A5013252589 @default.
• W2499951825 creator A5031185611 @default.
• W2499951825 creator A5044609483 @default.
• W2499951825 creator A5045650596 @default.
• W2499951825 creator A5073214855 @default.
• W2499951825 date "2017-04-15" @default.
• W2499951825 modified "2023-09-23" @default.
• W2499951825 title "Inhibition of SKP2 Sensitizes Bromocriptine-Induced Apoptosis in Human Prolactinoma Cells" @default.
• W2499951825 cites W128920855 @default.
• W2499951825 cites W1932848144 @default.
• W2499951825 cites W1988898379 @default.
• W2499951825 cites W1991630894 @default.
• W2499951825 cites W1999864475 @default.
• W2499951825 cites W2014875885 @default.
• W2499951825 cites W2016540525 @default.
• W2499951825 cites W2017283375 @default.
• W2499951825 cites W2020235979 @default.
• W2499951825 cites W2029122973 @default.
• W2499951825 cites W2031944627 @default.
• W2499951825 cites W2040423711 @default.
• W2499951825 cites W2049706724 @default.
• W2499951825 cites W2059515586 @default.
• W2499951825 cites W2067734857 @default.
• W2499951825 cites W2083450231 @default.
• W2499951825 cites W2090358177 @default.
• W2499951825 cites W2090398112 @default.
• W2499951825 cites W2101176202 @default.
• W2499951825 cites W2103243586 @default.
• W2499951825 cites W2111837687 @default.
• W2499951825 cites W2117450989 @default.
• W2499951825 cites W2143024729 @default.
• W2499951825 cites W2151456537 @default.
• W2499951825 cites W2156698829 @default.
• W2499951825 cites W2168100062 @default.
• W2499951825 cites W2170634115 @default.
• W2499951825 cites W2195571213 @default.
• W2499951825 cites W4249627078 @default.
• W2499951825 doi "https://doi.org/10.4143/crt.2016.017" @default.
• W2499951825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5398389" @default.
• W2499951825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27488872" @default.
• W2499951825 hasPublicationYear "2017" @default.
• W2499951825 type Work @default.
• W2499951825 sameAs 2499951825 @default.
• W2499951825 citedByCount "13" @default.
• W2499951825 countsByYear W24999518252017 @default.
• W2499951825 countsByYear W24999518252018 @default.
• W2499951825 countsByYear W24999518252019 @default.
• W2499951825 countsByYear W24999518252020 @default.
• W2499951825 countsByYear W24999518252021 @default.
• W2499951825 countsByYear W24999518252022 @default.
• W2499951825 crossrefType "journal-article" @default.
• W2499951825 hasAuthorship W2499951825A5003753493 @default.
• W2499951825 hasAuthorship W2499951825A5008623292 @default.
• W2499951825 hasAuthorship W2499951825A5013252589 @default.
• W2499951825 hasAuthorship W2499951825A5031185611 @default.
• W2499951825 hasAuthorship W2499951825A5044609483 @default.
• W2499951825 hasAuthorship W2499951825A5045650596 @default.
• W2499951825 hasAuthorship W2499951825A5073214855 @default.
• W2499951825 hasBestOaLocation W24999518251 @default.
• W2499951825 hasConcept C104317684 @default.
• W2499951825 hasConcept C126322002 @default.
• W2499951825 hasConcept C134018914 @default.
• W2499951825 hasConcept C134459356 @default.
• W2499951825 hasConcept C170493617 @default.
• W2499951825 hasConcept C190283241 @default.
• W2499951825 hasConcept C25602115 @default.
• W2499951825 hasConcept C2776787872 @default.
• W2499951825 hasConcept C2776856834 @default.
• W2499951825 hasConcept C2778258207 @default.
• W2499951825 hasConcept C2778918492 @default.
• W2499951825 hasConcept C2778938600 @default.
• W2499951825 hasConcept C2779064019 @default.
• W2499951825 hasConcept C502942594 @default.
• W2499951825 hasConcept C55493867 @default.
• W2499951825 hasConcept C71315377 @default.
• W2499951825 hasConcept C71924100 @default.
• W2499951825 hasConcept C86803240 @default.
• W2499951825 hasConceptScore W2499951825C104317684 @default.
• W2499951825 hasConceptScore W2499951825C126322002 @default.
• W2499951825 hasConceptScore W2499951825C134018914 @default.
• W2499951825 hasConceptScore W2499951825C134459356 @default.
• W2499951825 hasConceptScore W2499951825C170493617 @default.
• W2499951825 hasConceptScore W2499951825C190283241 @default.
• W2499951825 hasConceptScore W2499951825C25602115 @default.
• W2499951825 hasConceptScore W2499951825C2776787872 @default.
• W2499951825 hasConceptScore W2499951825C2776856834 @default.
• W2499951825 hasConceptScore W2499951825C2778258207 @default.
• W2499951825 hasConceptScore W2499951825C2778918492 @default.
• W2499951825 hasConceptScore W2499951825C2778938600 @default.
• W2499951825 hasConceptScore W2499951825C2779064019 @default.
• W2499951825 hasConceptScore W2499951825C502942594 @default.
• W2499951825 hasConceptScore W2499951825C55493867 @default.
• W2499951825 hasConceptScore W2499951825C71315377 @default.
• W2499951825 hasConceptScore W2499951825C71924100 @default.

• next