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• W2500009968 abstract "Amphiphilic molecules such as phospholipids, glycolipids, and monoacylglycerols (Figure 2.1) can spontaneously self-assemble into a wide range of ordered lyotropic liquid-crystalline mesophases (Shearman et al., 2006, 2010). The structural ordering within such phases can extend from the nanoscale (2–3 nm), up to much larger values (>100 nm), although locally the molecules are liquidlike.* Such lyotropic phases, in addition to their great relevance to understanding biological membrane structures, also have great potential in applications such as nanoencapsulation, nanoreactors, drug delivery, gene transfer, and delivery of Si-RNA to cells (Fong and Drummond, 2012, Leal et al., 2010). Apart from the bilayer lamellar Lα phase, all other fluid lyotropic mesophases are based upon ordered arrangements of curved interfaces, separating the amphiphiles from the water regions. These ordered curved phases may be divided into three main structural classes: 2D packings of cylindrical interfaces (discontinuous phases), 3D packings of saddle surfaces (bicontinuous phases), and 3D packings of spherical/ellipsoidal interfaces (discontinuous phases). Furthermore, each of these three classes occurs in two variants, either oil-in-water (type I), where the interfaces have net mean curvature toward the lipid hydrocarbon chain regions, or water-in-oil (inverse, type II), where the interfaces curve toward the water regions and away from the hydrocarbon chains (Figure 2.2). Type I curved mesophases generally break up into disordered micellar solutions upon high dilution in water. Type II mesophases, on the other hand, are usually stable in the presence of an excess" @default.
• W2500009968 created "2016-08-23" @default.
• W2500009968 creator A5025064847 @default.
• W2500009968 creator A5067713493 @default.
• W2500009968 date "2014-02-19" @default.
• W2500009968 modified "2023-09-24" @default.
• W2500009968 title "Nonlamellar Lipid Aggregates" @default.
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• W2500009968 doi "https://doi.org/10.1201/b16617-4" @default.
• W2500009968 hasPublicationYear "2014" @default.
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