Matches in SemOpenAlex for { <https://semopenalex.org/work/W2500013495> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2500013495 abstract "Vitamin E comprises a family of four tocopherols and four tocotrienols (α, β-, γ- and δ-), all of them antioxidants compounds. α-Tocopherol (α-T) showed superior biological activity [1] over the other compounds and is the major tocopherol present in blood and tissues [2]. Being antioxidant α-T reduce oxidative stress (OS) and could be implicated in the etiopathology of a number of diseases as reducing the risk of cancer, cardiovascular and neurodegenerative diseases [3]. This experimental work have been focused to develop a high quality, specific and fast analytical methodology for determination of α-T in biological samples using LC-ESI-MS. For that, chromatographic (mobile phase composition and flow, temperature and column C-18 2.1 x 50 mm-1.8 μm), electrospray ionization (negative) and mass spectrometric parameters (quali and quanti transitions, gas flow and temperature, nebulizer) have been carefully optimized. In addition, validation procedure (precision, recoveries, limits of quantitation, linearity…) have been carried out using a deutered compound of α-T (d6-α-T) in order to obtain a reproducible, sensible and accuracy analytical method. The optimized and validated analytical method has been applied for determination of concentration of α-T in serum and plasma samples. The pretreatment of biological samples from total blood have been also optimized." @default.
- W2500013495 created "2016-08-23" @default.
- W2500013495 creator A5020693699 @default.
- W2500013495 creator A5022370877 @default.
- W2500013495 creator A5034691666 @default.
- W2500013495 creator A5036258487 @default.
- W2500013495 creator A5046842805 @default.
- W2500013495 creator A5068344972 @default.
- W2500013495 creator A5087449273 @default.
- W2500013495 creator A5091112197 @default.
- W2500013495 date "2016-05-04" @default.
- W2500013495 modified "2023-09-26" @default.
- W2500013495 title "High precision, good recovery and fast determination of alfa-tocopherol (Vitamin E) in serum and plasma samples? This is your analytical method" @default.
- W2500013495 doi "https://doi.org/10.18143/jisanh_v3i3_1244" @default.
- W2500013495 hasPublicationYear "2016" @default.
- W2500013495 type Work @default.
- W2500013495 sameAs 2500013495 @default.
- W2500013495 citedByCount "0" @default.
- W2500013495 crossrefType "journal-article" @default.
- W2500013495 hasAuthorship W2500013495A5020693699 @default.
- W2500013495 hasAuthorship W2500013495A5022370877 @default.
- W2500013495 hasAuthorship W2500013495A5034691666 @default.
- W2500013495 hasAuthorship W2500013495A5036258487 @default.
- W2500013495 hasAuthorship W2500013495A5046842805 @default.
- W2500013495 hasAuthorship W2500013495A5068344972 @default.
- W2500013495 hasAuthorship W2500013495A5087449273 @default.
- W2500013495 hasAuthorship W2500013495A5091112197 @default.
- W2500013495 hasConcept C162356407 @default.
- W2500013495 hasConcept C185592680 @default.
- W2500013495 hasConcept C2777551382 @default.
- W2500013495 hasConcept C2778004101 @default.
- W2500013495 hasConcept C2781449162 @default.
- W2500013495 hasConcept C40684141 @default.
- W2500013495 hasConcept C43617362 @default.
- W2500013495 hasConcept C55493867 @default.
- W2500013495 hasConceptScore W2500013495C162356407 @default.
- W2500013495 hasConceptScore W2500013495C185592680 @default.
- W2500013495 hasConceptScore W2500013495C2777551382 @default.
- W2500013495 hasConceptScore W2500013495C2778004101 @default.
- W2500013495 hasConceptScore W2500013495C2781449162 @default.
- W2500013495 hasConceptScore W2500013495C40684141 @default.
- W2500013495 hasConceptScore W2500013495C43617362 @default.
- W2500013495 hasConceptScore W2500013495C55493867 @default.
- W2500013495 hasIssue "3" @default.
- W2500013495 hasLocation W25000134951 @default.
- W2500013495 hasOpenAccess W2500013495 @default.
- W2500013495 hasPrimaryLocation W25000134951 @default.
- W2500013495 hasRelatedWork W1966848530 @default.
- W2500013495 hasRelatedWork W2033489315 @default.
- W2500013495 hasRelatedWork W2092804050 @default.
- W2500013495 hasRelatedWork W2289510928 @default.
- W2500013495 hasRelatedWork W2408934226 @default.
- W2500013495 hasRelatedWork W2741114095 @default.
- W2500013495 hasRelatedWork W2782751513 @default.
- W2500013495 hasRelatedWork W2793893761 @default.
- W2500013495 hasRelatedWork W2806212379 @default.
- W2500013495 hasRelatedWork W2808965489 @default.
- W2500013495 hasRelatedWork W2885596676 @default.
- W2500013495 hasRelatedWork W2899572724 @default.
- W2500013495 hasRelatedWork W2927833619 @default.
- W2500013495 hasRelatedWork W3010420188 @default.
- W2500013495 hasRelatedWork W3022259291 @default.
- W2500013495 hasRelatedWork W3023532775 @default.
- W2500013495 hasRelatedWork W3044986436 @default.
- W2500013495 hasRelatedWork W3083487607 @default.
- W2500013495 hasRelatedWork W3186371276 @default.
- W2500013495 hasRelatedWork W2290303778 @default.
- W2500013495 hasVolume "3" @default.
- W2500013495 isParatext "false" @default.
- W2500013495 isRetracted "false" @default.
- W2500013495 magId "2500013495" @default.
- W2500013495 workType "article" @default.