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• W2500133844 abstract "We report that through facile lipid self-assembly, biomimetic membrane-conjugated mesoporous silica-coated graphene oxide is constructed as targeting nanocarrier toward efficient combination of photothermal therapy and chemotherapy. Impressively, the simple surface modification with folate-contained lipid bilayer allows the graphene-based nanoarchitecture above to be selectively internalized by tumor cells overexpressing relevant receptors. Compared to pure drug, 7-fold doxorubicin is delivered into tumor cells by the nanoarchitecture. After cellular internalization, upon near infrared light illumination, graphene oxide in the nanoarchitecture can convert light energy into heat to kill cancer cells partially. Simultaneously, hyperthermia will drive rapid release of doxorubicin from the nanoarchitecture above to further cause the death of more cancer cells. Thus, integrated cancer treatment with higher efficacy is achieved in vitro compared to that of individual therapy." @default.
• W2500133844 created "2016-08-23" @default.
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• W2500133844 date "2016-11-01" @default.
• W2500133844 modified "2023-10-17" @default.
• W2500133844 title "Biomimetic membrane-conjugated graphene nanoarchitecture for light-manipulating combined cancer treatment in vitro" @default.
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• W2500133844 doi "https://doi.org/10.1016/j.jcis.2016.07.031" @default.
• W2500133844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27497233" @default.
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