FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2500205151> ?p ?o ?g. }

• W2500205151 endingPage "347" @default.
• W2500205151 startingPage "339" @default.
• W2500205151 abstract "Combined overall survival (OS) analysis of Lux-Lung 3 and Lux-Lung 6 demonstrated that patients with epidermal growth factor receptor (EGFR) exon 19 deletions (Del19) would benefit from first-line second generation EGFR tyrosine kinase inhibitors (TKIs) afatinib but not for those with L858R. This study was to investigate the survival difference between first-line first generation EGFR-TKIs and chemotherapy in patients with either Del19 or L858R, and to directly compare OS in these two mutation groups.Eligibles were all prospective and retrospective studies comparing EGFR-TKIs with conventional chemotherapy or receiving single agent EGFR-TKIs and demonstrating survival analysis based on mutation types. The primary outcome was OS measured as pooled hazard ratios (HRs). All measures were pooled using randomeffects models and 95% confidential interval (95% CI) was calculated.A total of 14 studies incorporating 1,706 patients with either Del19 or L858R were included. Enrolling patients with Del19 or L858R in randomized controlled trials (RCTs), first-line first generation EGFR-TKIs were associated with no OS benefit, compared with chemotherapy (pooled HRTKI/Chemo for Del19: 0.82, 95% CI: 0.64-1.06, P = 0.14; pooled HRTKI/Chemo for L858R: 1.15, 95% CI: 0.85-1.56, P = 0.38). Direct comparison of Del19 with L858R receiving with first-line first generation EGFR-TKIs demonstrated no significant survival difference (pooled HR19/21: 0.88, 95% CI: 0.67-1.16, P = 0.37).Among patients with advanced non-small cell lung cancer (NSCLC) harboring Del19 and L858R, first-line first generation EGFR-TKIs demonstrated no survival benefit comparing with chemotherapy. Direct comparison between Del19 and L858R revealed no significant survival difference after first-line first generation EGFR-TKIs." @default.
• W2500205151 created "2016-08-23" @default.
• W2500205151 creator A5004598929 @default.
• W2500205151 creator A5014800253 @default.
• W2500205151 creator A5038306289 @default.
• W2500205151 creator A5046765289 @default.
• W2500205151 creator A5057744043 @default.
• W2500205151 creator A5067592367 @default.
• W2500205151 creator A5070926877 @default.
• W2500205151 date "2016-01-01" @default.
• W2500205151 modified "2023-09-22" @default.
• W2500205151 title "Comparing overall survival between first generation EGFR-TKIs and chemotherapy in lung cancer patients with Del19/L858R" @default.
• W2500205151 cites W1523413020 @default.
• W2500205151 cites W1546678577 @default.
• W2500205151 cites W1988370923 @default.
• W2500205151 cites W1990709725 @default.
• W2500205151 cites W1995653433 @default.
• W2500205151 cites W1998499306 @default.
• W2500205151 cites W2012932483 @default.
• W2500205151 cites W2022572106 @default.
• W2500205151 cites W2023816433 @default.
• W2500205151 cites W2024931783 @default.
• W2500205151 cites W2063391304 @default.
• W2500205151 cites W2094771796 @default.
• W2500205151 cites W2095618958 @default.
• W2500205151 cites W2096198395 @default.
• W2500205151 cites W2097965368 @default.
• W2500205151 cites W2100047106 @default.
• W2500205151 cites W2111662961 @default.
• W2500205151 cites W2121641332 @default.
• W2500205151 cites W2125435699 @default.
• W2500205151 cites W2129360604 @default.
• W2500205151 cites W2129656399 @default.
• W2500205151 cites W2132157071 @default.
• W2500205151 cites W2132870547 @default.
• W2500205151 cites W2134978639 @default.
• W2500205151 cites W2135192471 @default.
• W2500205151 cites W2138851777 @default.
• W2500205151 cites W2144459488 @default.
• W2500205151 cites W2149733252 @default.
• W2500205151 cites W2150485455 @default.
• W2500205151 cites W2160982674 @default.
• W2500205151 cites W2166084034 @default.
• W2500205151 cites W2168554121 @default.
• W2500205151 cites W2168841302 @default.
• W2500205151 cites W2171139285 @default.
• W2500205151 cites W2210071992 @default.
• W2500205151 cites W2566863750 @default.
• W2500205151 cites W2806575069 @default.
• W2500205151 cites W3022903699 @default.
• W2500205151 doi "https://doi.org/10.21147/j.issn.1000-9604.2016.03.08" @default.
• W2500205151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4949279" @default.
• W2500205151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27478319" @default.
• W2500205151 hasPublicationYear "2016" @default.
• W2500205151 type Work @default.
• W2500205151 sameAs 2500205151 @default.
• W2500205151 citedByCount "9" @default.
• W2500205151 countsByYear W25002051512016 @default.
• W2500205151 countsByYear W25002051512017 @default.
• W2500205151 countsByYear W25002051512018 @default.
• W2500205151 countsByYear W25002051512019 @default.
• W2500205151 countsByYear W25002051512020 @default.
• W2500205151 countsByYear W25002051512021 @default.
• W2500205151 crossrefType "journal-article" @default.
• W2500205151 hasAuthorship W2500205151A5004598929 @default.
• W2500205151 hasAuthorship W2500205151A5014800253 @default.
• W2500205151 hasAuthorship W2500205151A5038306289 @default.
• W2500205151 hasAuthorship W2500205151A5046765289 @default.
• W2500205151 hasAuthorship W2500205151A5057744043 @default.
• W2500205151 hasAuthorship W2500205151A5067592367 @default.
• W2500205151 hasAuthorship W2500205151A5070926877 @default.
• W2500205151 hasBestOaLocation W25002051512 @default.
• W2500205151 hasConcept C121608353 @default.
• W2500205151 hasConcept C126322002 @default.
• W2500205151 hasConcept C143998085 @default.
• W2500205151 hasConcept C207103383 @default.
• W2500205151 hasConcept C2776256026 @default.
• W2500205151 hasConcept C2776694085 @default.
• W2500205151 hasConcept C2778087573 @default.
• W2500205151 hasConcept C2779438470 @default.
• W2500205151 hasConcept C2780586478 @default.
• W2500205151 hasConcept C44249647 @default.
• W2500205151 hasConcept C71924100 @default.
• W2500205151 hasConceptScore W2500205151C121608353 @default.
• W2500205151 hasConceptScore W2500205151C126322002 @default.
• W2500205151 hasConceptScore W2500205151C143998085 @default.
• W2500205151 hasConceptScore W2500205151C207103383 @default.
• W2500205151 hasConceptScore W2500205151C2776256026 @default.
• W2500205151 hasConceptScore W2500205151C2776694085 @default.
• W2500205151 hasConceptScore W2500205151C2778087573 @default.
• W2500205151 hasConceptScore W2500205151C2779438470 @default.
• W2500205151 hasConceptScore W2500205151C2780586478 @default.
• W2500205151 hasConceptScore W2500205151C44249647 @default.
• W2500205151 hasConceptScore W2500205151C71924100 @default.
• W2500205151 hasIssue "3" @default.
• W2500205151 hasLocation W25002051511 @default.
• W2500205151 hasLocation W25002051512 @default.
• W2500205151 hasLocation W25002051513 @default.

• next