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- W250022912 abstract "Abstract : The identification of genes, which play a critical role in malignant transformation of the ovarian epithelium, will allow developing molecular tools for detection or intervention of altered activities in ovarian cancer, a cancer, which is often discovered in a late stage and with poor prognosis. Protein kinases such as p2l- activated kinases (Paks) are valuable targets for pharmacological intervention. Our project will elucidate alternative molecular mechanisms, present in ovarian cancer cell lines, which lead to hyperactive Pak. The effect of Pak activity on ovarian cell functions and detection of active Pak in tissues are additional goals. Radiolabeled ovarian cancer cell lines were screened for the presence of activating Pak tyrosine phosphorylation. Our data suggest that this mechanism is not prevalent in these cells. Next approaches will include adenoviral infection of dominant negative signaling molecules and the use of pharmacological inhibitors specific for certain growth factor receptors. Anti-phospho Pak antibody production was not successful, but similar antibodies produced by collaborators will be used for further Pak studies. The influence of Pak on cancer cell proliferation will be delineated with inducible cell lines. Increased knowledge about Pak signaling in cancer is an important step towards Pak inhibitor development." @default.
- W250022912 created "2016-06-24" @default.
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- W250022912 date "2001-08-01" @default.
- W250022912 modified "2023-09-27" @default.
- W250022912 title "Regulation and Function of Pak Signaling in Ovarian Cancer" @default.
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