FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2500374959> ?p ?o ?g. }

• W2500374959 endingPage "928" @default.
• W2500374959 startingPage "924" @default.
• W2500374959 abstract "Alpha-synuclein (α-Syn), a small (14 kDa) protein associated with Parkinson's disease, is abundant in human neural tissues. α-Syn plays an important role in maintaining a supply of synaptic vesicles in presynaptic terminals; however, the mechanism by which it performs this function are not well understood. In addition, there is a correlation between α-Syn over-expression and upregulation of an innate immune response. Given the growing body of literature surrounding antimicrobial peptides (AMPs) in the brain, and the similarities between α-Syn and a previously characterized AMP, Amyloid-β, we set out to investigate if α-Syn shares AMP-like properties. Here we demonstrate that α-Syn exhibits antibacterial activity against Escherichia coli and Staphylococcus aureus. In addition, we demonstrate a role for α-Syn in inhibiting various pathogenic fungal strains such as Aspergillus flavus, Aspergillus fumigatus and Rhizoctonia solani. We also analyzed localizations of recombinant α-Syn protein in E. coli and Candida albicans. These results suggest that in addition to α-Syn's role in neurotransmitter release, it appears to be a natural AMP." @default.
• W2500374959 created "2016-08-23" @default.
• W2500374959 creator A5000289036 @default.
• W2500374959 creator A5002201230 @default.
• W2500374959 creator A5006173861 @default.
• W2500374959 creator A5008324988 @default.
• W2500374959 creator A5012770069 @default.
• W2500374959 creator A5019178023 @default.
• W2500374959 creator A5022373158 @default.
• W2500374959 creator A5033106740 @default.
• W2500374959 creator A5076722996 @default.
• W2500374959 date "2016-09-01" @default.
• W2500374959 modified "2023-10-02" @default.
• W2500374959 title "Functional characterization of alpha-synuclein protein with antimicrobial activity" @default.
• W2500374959 cites W139563923 @default.
• W2500374959 cites W181966998 @default.
• W2500374959 cites W1897859562 @default.
• W2500374959 cites W1970429881 @default.
• W2500374959 cites W1972565924 @default.
• W2500374959 cites W1992187783 @default.
• W2500374959 cites W2003973146 @default.
• W2500374959 cites W2004094034 @default.
• W2500374959 cites W2007767060 @default.
• W2500374959 cites W2023250031 @default.
• W2500374959 cites W2028491301 @default.
• W2500374959 cites W2032911291 @default.
• W2500374959 cites W2040042139 @default.
• W2500374959 cites W2043835731 @default.
• W2500374959 cites W2045370755 @default.
• W2500374959 cites W2062056914 @default.
• W2500374959 cites W2080958826 @default.
• W2500374959 cites W2081032574 @default.
• W2500374959 cites W2087000747 @default.
• W2500374959 cites W2104771760 @default.
• W2500374959 cites W2106343176 @default.
• W2500374959 cites W2108629610 @default.
• W2500374959 cites W2117403977 @default.
• W2500374959 cites W2144502720 @default.
• W2500374959 cites W2147215573 @default.
• W2500374959 cites W2178750505 @default.
• W2500374959 cites W2333426312 @default.
• W2500374959 cites W4233416471 @default.
• W2500374959 cites W827822672 @default.
• W2500374959 doi "https://doi.org/10.1016/j.bbrc.2016.08.052" @default.
• W2500374959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27520375" @default.
• W2500374959 hasPublicationYear "2016" @default.
• W2500374959 type Work @default.
• W2500374959 sameAs 2500374959 @default.
• W2500374959 citedByCount "75" @default.
• W2500374959 countsByYear W25003749592017 @default.
• W2500374959 countsByYear W25003749592018 @default.
• W2500374959 countsByYear W25003749592019 @default.
• W2500374959 countsByYear W25003749592020 @default.
• W2500374959 countsByYear W25003749592021 @default.
• W2500374959 countsByYear W25003749592022 @default.
• W2500374959 countsByYear W25003749592023 @default.
• W2500374959 crossrefType "journal-article" @default.
• W2500374959 hasAuthorship W2500374959A5000289036 @default.
• W2500374959 hasAuthorship W2500374959A5002201230 @default.
• W2500374959 hasAuthorship W2500374959A5006173861 @default.
• W2500374959 hasAuthorship W2500374959A5008324988 @default.
• W2500374959 hasAuthorship W2500374959A5012770069 @default.
• W2500374959 hasAuthorship W2500374959A5019178023 @default.
• W2500374959 hasAuthorship W2500374959A5022373158 @default.
• W2500374959 hasAuthorship W2500374959A5033106740 @default.
• W2500374959 hasAuthorship W2500374959A5076722996 @default.
• W2500374959 hasConcept C104317684 @default.
• W2500374959 hasConcept C136449434 @default.
• W2500374959 hasConcept C142724271 @default.
• W2500374959 hasConcept C203014093 @default.
• W2500374959 hasConcept C2777292910 @default.
• W2500374959 hasConcept C2779134260 @default.
• W2500374959 hasConcept C2779489039 @default.
• W2500374959 hasConcept C2779734285 @default.
• W2500374959 hasConcept C2779787849 @default.
• W2500374959 hasConcept C2780476228 @default.
• W2500374959 hasConcept C2780917455 @default.
• W2500374959 hasConcept C2781449126 @default.
• W2500374959 hasConcept C40767141 @default.
• W2500374959 hasConcept C4937899 @default.
• W2500374959 hasConcept C523546767 @default.
• W2500374959 hasConcept C540938839 @default.
• W2500374959 hasConcept C54355233 @default.
• W2500374959 hasConcept C547475151 @default.
• W2500374959 hasConcept C55493867 @default.
• W2500374959 hasConcept C59822182 @default.
• W2500374959 hasConcept C71924100 @default.
• W2500374959 hasConcept C86803240 @default.
• W2500374959 hasConcept C8891405 @default.
• W2500374959 hasConcept C89423630 @default.
• W2500374959 hasConceptScore W2500374959C104317684 @default.
• W2500374959 hasConceptScore W2500374959C136449434 @default.
• W2500374959 hasConceptScore W2500374959C142724271 @default.
• W2500374959 hasConceptScore W2500374959C203014093 @default.
• W2500374959 hasConceptScore W2500374959C2777292910 @default.
• W2500374959 hasConceptScore W2500374959C2779134260 @default.
• W2500374959 hasConceptScore W2500374959C2779489039 @default.
• W2500374959 hasConceptScore W2500374959C2779734285 @default.

• next