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• W2500424012 abstract "// Catherine Gallou 1 , Aude Rougeot 1 , Stéphanie Graff-Dubois 2 , Kostas Kosmatopoulos 1 , Jeanne Menez-Jamet 1 1 Vaxon Biotech, 75015, Paris, France 2 University Pierre-and-Marie-Curie (aka University Paris 06), INSERM U1135, CNRS ERL8255, 75013, Paris, France Correspondence to: Jeanne Menez-Jamet, email: jmenez@vaxon-biotech.com Keywords: HLA-B7, vaccination, immunotherapy, optimized, cryptic Received: May 27, 2016      Accepted: July 13, 2016      Published: August 05, 2016 ABSTRACT Tumor Associated Antigens (TAAs) are the privileged targets of almost all the cancer vaccines tested to date. Unfortunately all these vaccines failed to show a clinical efficacy. The main reason for this failure is the immune tolerance to TAAs that are self-proteins expressed by normal and cancer cells. Self-tolerance to TAAs is directed against their dominant rather than against their cryptic epitopes. The best way to overcome self-tolerance to TAAs would therefore be to target their cryptic epitopes. However, because of their low HLA-I affinity, cryptic peptides are non-immunogenic and cannot be used to stimulate an antitumor immune response unless their immunogenicity has been previously enhanced. In this paper we describe a general approach to enhance immunogenicity of almost all the HLA-B*0702 restricted cryptic peptides derived from TAAs. It consists in substituting residues at position 1 or 9 of low HLA-B*0702 affinity cryptic peptides by an Alanine or a Leucine respectively. These substitutions increase affinity of peptides for HLA-B*0702. These optimized cryptic peptides are strongly immunogenic and very importantly CTL they stimulate recognize their native counterparts. TAAs derived optimized cryptic peptides can be considered as universal antitumor vaccine since they escape self-tolerance, are immunogenic and are not patient specific." @default.
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• W2500424012 date "2016-08-05" @default.
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• W2500424012 title "A general strategy to optimize immunogenicity of HLA-B*0702 restricted cryptic peptides from tumor associated antigens: Design of universal neo-antigen like tumor vaccines for HLA-B*0702 positive patients" @default.
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• W2500424012 doi "https://doi.org/10.18632/oncotarget.11086" @default.
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