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• W2500441434 abstract "As catheter-based renal denervation (RDN) has been a recently introduced invasive treatment, confirming the safety of the procedure has been a central issue in the conducted trials. Preclinical data have identified limited changes in the vessel wall including local oedema, thrombus formation and fibrosis. Clinical trials reported only few periprocedural adverse events such as access site complications and renal artery dissections, while follow-up of patients for up to 3 years showed that this is an overall safe procedure. Adverse events potentially associated with autonomic dysfunction, such as orthostatic hypotension, have been rare and in general not associated with RDN. A number of reports on new renal artery stenosis, theoretically associated with the radiofrequency-induced tissue injury, have raised concerns for such a complication, even though the relative incidence is notably small. In trials with different catheters as well as running registries, renal function has been shown to remain stable or mildly deteriorate. Thorough recording of events in all studies as well as comparisons of safety among current and developing devices are pivotal in order to provide a clearer picture of long-term safety." @default.
• W2500441434 created "2016-08-23" @default.
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• W2500441434 date "2016-01-01" @default.
• W2500441434 modified "2023-09-23" @default.
• W2500441434 title "Safety of Renal Denervation" @default.
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• W2500441434 doi "https://doi.org/10.1007/978-3-319-34141-5_15" @default.
• W2500441434 hasPublicationYear "2016" @default.
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