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• W2500563886 abstract "Summary Nodal marginal zone lymphoma ( NMZL ) is a rare non‐Hodgkin lymphoma that arises from mature B‐cells. We delineate outcomes, prognostic factors and treatment trends among a large cohort of patients with NMZL in the rituximab era. We identified 56 such patients treated at our institutions. The majority presented with advanced stage disease (78·6%). Over a median follow‐up of 38·2 months, median progression‐free survival ( PFS ) was 42·4 months and median overall survival ( OS ) was not reached. Kaplan–Meier estimates of OS at 120 months after diagnosis was 71·9%. High‐risk follicular lymphoma international prognostic index ( FLIPI ) was associated with inferior PFS . Age >60 years and elevated serum lactate dehydrogenase ( LDH ) were associated with inferior OS . Transformation to diffuse large B‐cell lymphoma occurred in 7 patients, 6 of who presented with advanced disease. OS was comparable to our previously reported extranodal MZL cohort. FLIPI score predicted for inferior PFS and OS when both cohorts were analysed together ( n = 267). In summary, outcomes in NMZL are favourable with a large majority of patients surviving at 120 months. High risk FLIPI , age >60 years, and elevated serum LDH were associated with inferior outcomes." @default.
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• W2500563886 date "2016-07-22" @default.
• W2500563886 modified "2023-10-04" @default.
• W2500563886 title "Dual institution experience of nodal marginal zone lymphoma reveals excellent long-term outcomes in the rituximab era" @default.
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• W2500563886 doi "https://doi.org/10.1111/bjh.14228" @default.
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