FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2500731645> ?p ?o ?g. }

• W2500731645 endingPage "13453" @default.
• W2500731645 startingPage "13445" @default.
• W2500731645 abstract "SLC5A8 has been shown to be associated with a large number of cancer progressions. However, the biological functions of SLC5A8 in hepatocellular carcinoma (HCC) remain largely unclear. Therefore, we performed this research to explore the functions of SLC5A8 in HCC progression. In this study, SLC5A8 protein and mRNA expression were examined by immunohistochemistry and quantitative real-time PCR, respectively, and we found significantly lower expression levels in HCCs than in the corresponding normal liver tissues. Low SLC5A8 expression was significantly correlated with the clinicopathological features of HCC patients. Patients with low SLC5A8 expression have a shorter overall survival time. This interpretation is confirmed by the results obtained from our in vitro experiments; functional assays indicated that overexpression of SLC5A8, by infection with a recombinant plasmid containing SLC5A8, significantly suppressed HCC cell growth, invasion, and migration and induced HCC cell apoptosis. Moreover, the expression levels of beta-catenin, cyclin D1, c-Myc, MMP-2, and FAK detected by western blotting were downregulated in SLC5A8-transfected HCC cells compared with control-transfected cells, indicating that SLC5A8 has a tumor-suppressive function that acts by interfering with Wnt/β-catenin signaling in HCC." @default.
• W2500731645 created "2016-08-23" @default.
• W2500731645 creator A5021989628 @default.
• W2500731645 creator A5037534561 @default.
• W2500731645 creator A5042050423 @default.
• W2500731645 creator A5050346034 @default.
• W2500731645 date "2016-07-27" @default.
• W2500731645 modified "2023-10-03" @default.
• W2500731645 title "Downregulation of SLC5A8 inhibits hepatocellular carcinoma progression through regulation of Wnt/β-catenin signaling" @default.
• W2500731645 cites W1968305925 @default.
• W2500731645 cites W1970060716 @default.
• W2500731645 cites W1972600888 @default.
• W2500731645 cites W1977087431 @default.
• W2500731645 cites W1977094821 @default.
• W2500731645 cites W1983218872 @default.
• W2500731645 cites W1985706014 @default.
• W2500731645 cites W2022075338 @default.
• W2500731645 cites W2027765481 @default.
• W2500731645 cites W2031960765 @default.
• W2500731645 cites W2032268024 @default.
• W2500731645 cites W2036547532 @default.
• W2500731645 cites W2069441798 @default.
• W2500731645 cites W2079476845 @default.
• W2500731645 cites W2083855057 @default.
• W2500731645 cites W2088629624 @default.
• W2500731645 cites W2091482921 @default.
• W2500731645 cites W2124652061 @default.
• W2500731645 cites W2128581106 @default.
• W2500731645 cites W2137794530 @default.
• W2500731645 cites W2157123244 @default.
• W2500731645 cites W2159686713 @default.
• W2500731645 cites W2168874600 @default.
• W2500731645 doi "https://doi.org/10.1007/s13277-016-5170-3" @default.
• W2500731645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27465549" @default.
• W2500731645 hasPublicationYear "2016" @default.
• W2500731645 type Work @default.
• W2500731645 sameAs 2500731645 @default.
• W2500731645 citedByCount "5" @default.
• W2500731645 countsByYear W25007316452017 @default.
• W2500731645 countsByYear W25007316452018 @default.
• W2500731645 countsByYear W25007316452021 @default.
• W2500731645 countsByYear W25007316452023 @default.
• W2500731645 crossrefType "journal-article" @default.
• W2500731645 hasAuthorship W2500731645A5021989628 @default.
• W2500731645 hasAuthorship W2500731645A5037534561 @default.
• W2500731645 hasAuthorship W2500731645A5042050423 @default.
• W2500731645 hasAuthorship W2500731645A5050346034 @default.
• W2500731645 hasConcept C104317684 @default.
• W2500731645 hasConcept C127561419 @default.
• W2500731645 hasConcept C137620995 @default.
• W2500731645 hasConcept C1491633281 @default.
• W2500731645 hasConcept C199835354 @default.
• W2500731645 hasConcept C2778019345 @default.
• W2500731645 hasConcept C2779314089 @default.
• W2500731645 hasConcept C2779324961 @default.
• W2500731645 hasConcept C29537977 @default.
• W2500731645 hasConcept C30145163 @default.
• W2500731645 hasConcept C502942594 @default.
• W2500731645 hasConcept C54009773 @default.
• W2500731645 hasConcept C54355233 @default.
• W2500731645 hasConcept C55493867 @default.
• W2500731645 hasConcept C62112901 @default.
• W2500731645 hasConcept C62478195 @default.
• W2500731645 hasConcept C71924100 @default.
• W2500731645 hasConcept C81885089 @default.
• W2500731645 hasConcept C85265743 @default.
• W2500731645 hasConcept C86803240 @default.
• W2500731645 hasConcept C95444343 @default.
• W2500731645 hasConceptScore W2500731645C104317684 @default.
• W2500731645 hasConceptScore W2500731645C127561419 @default.
• W2500731645 hasConceptScore W2500731645C137620995 @default.
• W2500731645 hasConceptScore W2500731645C1491633281 @default.
• W2500731645 hasConceptScore W2500731645C199835354 @default.
• W2500731645 hasConceptScore W2500731645C2778019345 @default.
• W2500731645 hasConceptScore W2500731645C2779314089 @default.
• W2500731645 hasConceptScore W2500731645C2779324961 @default.
• W2500731645 hasConceptScore W2500731645C29537977 @default.
• W2500731645 hasConceptScore W2500731645C30145163 @default.
• W2500731645 hasConceptScore W2500731645C502942594 @default.
• W2500731645 hasConceptScore W2500731645C54009773 @default.
• W2500731645 hasConceptScore W2500731645C54355233 @default.
• W2500731645 hasConceptScore W2500731645C55493867 @default.
• W2500731645 hasConceptScore W2500731645C62112901 @default.
• W2500731645 hasConceptScore W2500731645C62478195 @default.
• W2500731645 hasConceptScore W2500731645C71924100 @default.
• W2500731645 hasConceptScore W2500731645C81885089 @default.
• W2500731645 hasConceptScore W2500731645C85265743 @default.
• W2500731645 hasConceptScore W2500731645C86803240 @default.
• W2500731645 hasConceptScore W2500731645C95444343 @default.
• W2500731645 hasIssue "10" @default.
• W2500731645 hasLocation W25007316451 @default.
• W2500731645 hasLocation W25007316452 @default.
• W2500731645 hasOpenAccess W2500731645 @default.
• W2500731645 hasPrimaryLocation W25007316451 @default.
• W2500731645 hasRelatedWork W2050712818 @default.
• W2500731645 hasRelatedWork W2055205437 @default.
• W2500731645 hasRelatedWork W2100653306 @default.
• W2500731645 hasRelatedWork W2349185834 @default.

• next