Matches in SemOpenAlex for { <https://semopenalex.org/work/W2500736051> ?p ?o ?g. }
- W2500736051 endingPage "2256" @default.
- W2500736051 startingPage "2246" @default.
- W2500736051 abstract "Neuromodulators influence the activities of collections of neurons and have profound impacts on animal behavior. Male courtship drive is complex and subject to neuromodulatory control. Using the fruit fly Drosophila melanogaster, we identified neurons in the brain (inferior posterior slope; IPS) that impact courtship drive and were controlled by tyramine—a biogenic amine related to dopamine, whose roles in most animals are enigmatic. We knocked out a tyramine-specific receptor, TyrR, which was expressed in IPS neurons. Loss of TyrR led to a striking elevation in courtship activity between males. This effect occurred only in the absence of females, as TyrRGal4 mutant males exhibited a wild-type preference for females. Artificial hyperactivation of IPS neurons caused a large increase in male-male courtship, whereas suppression of IPS activity decreased male-female courtship. We conclude that TyrR is a receptor for tyramine, and suggest that it serves to curb high levels of courtship activity through functioning as an inhibitory neuromodulator." @default.
- W2500736051 created "2016-08-23" @default.
- W2500736051 creator A5026283201 @default.
- W2500736051 creator A5037039319 @default.
- W2500736051 creator A5059045594 @default.
- W2500736051 creator A5083760703 @default.
- W2500736051 creator A5087303620 @default.
- W2500736051 date "2016-09-01" @default.
- W2500736051 modified "2023-10-16" @default.
- W2500736051 title "Neuromodulation of Courtship Drive through Tyramine-Responsive Neurons in the Drosophila Brain" @default.
- W2500736051 cites W1652929228 @default.
- W2500736051 cites W1787449105 @default.
- W2500736051 cites W1971118536 @default.
- W2500736051 cites W1971175217 @default.
- W2500736051 cites W1972611219 @default.
- W2500736051 cites W1972690100 @default.
- W2500736051 cites W1977146259 @default.
- W2500736051 cites W1981892783 @default.
- W2500736051 cites W1994253350 @default.
- W2500736051 cites W1994713392 @default.
- W2500736051 cites W1996761102 @default.
- W2500736051 cites W1996980670 @default.
- W2500736051 cites W1997543121 @default.
- W2500736051 cites W1998038483 @default.
- W2500736051 cites W2002141216 @default.
- W2500736051 cites W2006641069 @default.
- W2500736051 cites W2007194485 @default.
- W2500736051 cites W2018861476 @default.
- W2500736051 cites W2019369321 @default.
- W2500736051 cites W2028791709 @default.
- W2500736051 cites W2037882476 @default.
- W2500736051 cites W2039528431 @default.
- W2500736051 cites W2043203446 @default.
- W2500736051 cites W2048080520 @default.
- W2500736051 cites W2054014550 @default.
- W2500736051 cites W2055099335 @default.
- W2500736051 cites W2060396426 @default.
- W2500736051 cites W2069480516 @default.
- W2500736051 cites W2081189558 @default.
- W2500736051 cites W2082397632 @default.
- W2500736051 cites W2084858930 @default.
- W2500736051 cites W2090551154 @default.
- W2500736051 cites W2094479282 @default.
- W2500736051 cites W2104738805 @default.
- W2500736051 cites W2113559961 @default.
- W2500736051 cites W2115286068 @default.
- W2500736051 cites W2129578030 @default.
- W2500736051 cites W2130088507 @default.
- W2500736051 cites W2136572360 @default.
- W2500736051 cites W2138062402 @default.
- W2500736051 cites W2138814742 @default.
- W2500736051 cites W2150861334 @default.
- W2500736051 cites W2161925837 @default.
- W2500736051 cites W2170816999 @default.
- W2500736051 cites W2171332611 @default.
- W2500736051 cites W2204710296 @default.
- W2500736051 cites W2346553109 @default.
- W2500736051 cites W2418925592 @default.
- W2500736051 cites W4249237144 @default.
- W2500736051 cites W4321318449 @default.
- W2500736051 doi "https://doi.org/10.1016/j.cub.2016.06.061" @default.
- W2500736051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5021585" @default.
- W2500736051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27498566" @default.
- W2500736051 hasPublicationYear "2016" @default.
- W2500736051 type Work @default.
- W2500736051 sameAs 2500736051 @default.
- W2500736051 citedByCount "37" @default.
- W2500736051 countsByYear W25007360512016 @default.
- W2500736051 countsByYear W25007360512017 @default.
- W2500736051 countsByYear W25007360512018 @default.
- W2500736051 countsByYear W25007360512019 @default.
- W2500736051 countsByYear W25007360512020 @default.
- W2500736051 countsByYear W25007360512021 @default.
- W2500736051 countsByYear W25007360512022 @default.
- W2500736051 countsByYear W25007360512023 @default.
- W2500736051 crossrefType "journal-article" @default.
- W2500736051 hasAuthorship W2500736051A5026283201 @default.
- W2500736051 hasAuthorship W2500736051A5037039319 @default.
- W2500736051 hasAuthorship W2500736051A5059045594 @default.
- W2500736051 hasAuthorship W2500736051A5083760703 @default.
- W2500736051 hasAuthorship W2500736051A5087303620 @default.
- W2500736051 hasBestOaLocation W25007360511 @default.
- W2500736051 hasConcept C104317684 @default.
- W2500736051 hasConcept C126322002 @default.
- W2500736051 hasConcept C130039590 @default.
- W2500736051 hasConcept C134018914 @default.
- W2500736051 hasConcept C169760540 @default.
- W2500736051 hasConcept C170493617 @default.
- W2500736051 hasConcept C24998067 @default.
- W2500736051 hasConcept C2775864247 @default.
- W2500736051 hasConcept C2776077682 @default.
- W2500736051 hasConcept C2776453541 @default.
- W2500736051 hasConcept C2780104201 @default.
- W2500736051 hasConcept C2780375056 @default.
- W2500736051 hasConcept C2780696224 @default.
- W2500736051 hasConcept C513476851 @default.
- W2500736051 hasConcept C54355233 @default.
- W2500736051 hasConcept C71924100 @default.