FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2500867121> ?p ?o ?g. }

• W2500867121 endingPage "463" @default.
• W2500867121 startingPage "451" @default.
• W2500867121 abstract "Despite the undeniable medical advances achieved in recent decades, cancer remains one of the main causes of mortality. It is thus extremely important to make every effort to discover new risk factors for this disease, particularly ones that can be treated or modified. Various pathophysiologic pathways have been postulated as possible causes of cancer or its increased aggressiveness, and also of greater resistance to antitumoral treatment, in the presence of both intermittent hypoxia and sleep fragmentation (both inherent to sleep apnea). Thus far, these biological hypotheses have been supported by various experimental studies in animals. Meanwhile, recent human studies drawing on preexisting databases have observed an increase in cancer incidence and mortality in patients with a greater severity of sleep-disordered breathing. However, the methodologic limitations of these studies (which are mostly retrospective and lack any measurement of direct markers of intermittent hypoxia or sleep fragmentation) highlight the need for controlled, prospective studies that would provide stronger scientific evidence regarding the existence of this association and its main characteristics, as well as explore its nature and origin in greater depth. The great epidemiologic impact of both cancer and sleep apnea and the potential for clinical treatment make this field of research an exciting challenge. Despite the undeniable medical advances achieved in recent decades, cancer remains one of the main causes of mortality. It is thus extremely important to make every effort to discover new risk factors for this disease, particularly ones that can be treated or modified. Various pathophysiologic pathways have been postulated as possible causes of cancer or its increased aggressiveness, and also of greater resistance to antitumoral treatment, in the presence of both intermittent hypoxia and sleep fragmentation (both inherent to sleep apnea). Thus far, these biological hypotheses have been supported by various experimental studies in animals. Meanwhile, recent human studies drawing on preexisting databases have observed an increase in cancer incidence and mortality in patients with a greater severity of sleep-disordered breathing. However, the methodologic limitations of these studies (which are mostly retrospective and lack any measurement of direct markers of intermittent hypoxia or sleep fragmentation) highlight the need for controlled, prospective studies that would provide stronger scientific evidence regarding the existence of this association and its main characteristics, as well as explore its nature and origin in greater depth. The great epidemiologic impact of both cancer and sleep apnea and the potential for clinical treatment make this field of research an exciting challenge. ResponseCHESTVol. 150Issue 6PreviewAt the outset, we wish to thank Dr Marvisi1 for his interest in our article. As the authors of the letter have stated, in the past few years some outstanding research groups have described other pathophysiological pathways linking OSA with cancer, some orchestrated by hypoxia2-5 and some by sleep fragmentation.2-4,6,7 Some of these pathways are related to alterations to the immune system in macrophages/monocytes, natural killer cells, lymphocytes, and other immune cells.2-7 Interesting studies and reviews of the role of microvesicles/exosomes and the impact on the sympathetic/catecholaminergic system and other pathophysiological pathways have recently been published. Full-Text PDF Cancer and OSA: Beyond HypoxiaCHESTVol. 150Issue 6PreviewI have read with great interest and pleasure the excellent review by Martínez-García et al1 entitled “Cancer and OSA: Current Evidence from Human Studies” published in CHEST (August 2016). The authors shed light on this important and aporetical topic. Full-Text PDF" @default.
• W2500867121 created "2016-08-23" @default.
• W2500867121 creator A5016043840 @default.
• W2500867121 creator A5075707927 @default.
• W2500867121 creator A5083014289 @default.
• W2500867121 date "2016-08-01" @default.
• W2500867121 modified "2023-10-16" @default.
• W2500867121 title "Cancer and OSA" @default.
• W2500867121 cites W1563588965 @default.
• W2500867121 cites W1872203079 @default.
• W2500867121 cites W1971017480 @default.
• W2500867121 cites W1991633169 @default.
• W2500867121 cites W2015511926 @default.
• W2500867121 cites W2028553108 @default.
• W2500867121 cites W2029901821 @default.
• W2500867121 cites W2031374244 @default.
• W2500867121 cites W2032232748 @default.
• W2500867121 cites W2042958005 @default.
• W2500867121 cites W2077967308 @default.
• W2500867121 cites W2083327363 @default.
• W2500867121 cites W2084009434 @default.
• W2500867121 cites W2084027288 @default.
• W2500867121 cites W2087790911 @default.
• W2500867121 cites W2106304703 @default.
• W2500867121 cites W2108281717 @default.
• W2500867121 cites W2110498811 @default.
• W2500867121 cites W2112072941 @default.
• W2500867121 cites W2117098447 @default.
• W2500867121 cites W2117834225 @default.
• W2500867121 cites W2122150741 @default.
• W2500867121 cites W2126868294 @default.
• W2500867121 cites W2130086113 @default.
• W2500867121 cites W2133396341 @default.
• W2500867121 cites W2135847753 @default.
• W2500867121 cites W2140540708 @default.
• W2500867121 cites W2142037875 @default.
• W2500867121 cites W2149638664 @default.
• W2500867121 cites W2150116734 @default.
• W2500867121 cites W2155302458 @default.
• W2500867121 cites W2171169531 @default.
• W2500867121 cites W2219430207 @default.
• W2500867121 cites W396030573 @default.
• W2500867121 cites W4242851810 @default.
• W2500867121 doi "https://doi.org/10.1016/j.chest.2016.04.029" @default.
• W2500867121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27164292" @default.
• W2500867121 hasPublicationYear "2016" @default.
• W2500867121 type Work @default.
• W2500867121 sameAs 2500867121 @default.
• W2500867121 citedByCount "54" @default.
• W2500867121 countsByYear W25008671212016 @default.
• W2500867121 countsByYear W25008671212017 @default.
• W2500867121 countsByYear W25008671212018 @default.
• W2500867121 countsByYear W25008671212019 @default.
• W2500867121 countsByYear W25008671212020 @default.
• W2500867121 countsByYear W25008671212021 @default.
• W2500867121 countsByYear W25008671212022 @default.
• W2500867121 countsByYear W25008671212023 @default.
• W2500867121 crossrefType "journal-article" @default.
• W2500867121 hasAuthorship W2500867121A5016043840 @default.
• W2500867121 hasAuthorship W2500867121A5075707927 @default.
• W2500867121 hasAuthorship W2500867121A5083014289 @default.
• W2500867121 hasConcept C121608353 @default.
• W2500867121 hasConcept C126322002 @default.
• W2500867121 hasConcept C142724271 @default.
• W2500867121 hasConcept C177713679 @default.
• W2500867121 hasConcept C2776006263 @default.
• W2500867121 hasConcept C2776256026 @default.
• W2500867121 hasConcept C2777935920 @default.
• W2500867121 hasConcept C2779134260 @default.
• W2500867121 hasConcept C2780796939 @default.
• W2500867121 hasConcept C60644358 @default.
• W2500867121 hasConcept C71924100 @default.
• W2500867121 hasConcept C86803240 @default.
• W2500867121 hasConceptScore W2500867121C121608353 @default.
• W2500867121 hasConceptScore W2500867121C126322002 @default.
• W2500867121 hasConceptScore W2500867121C142724271 @default.
• W2500867121 hasConceptScore W2500867121C177713679 @default.
• W2500867121 hasConceptScore W2500867121C2776006263 @default.
• W2500867121 hasConceptScore W2500867121C2776256026 @default.
• W2500867121 hasConceptScore W2500867121C2777935920 @default.
• W2500867121 hasConceptScore W2500867121C2779134260 @default.
• W2500867121 hasConceptScore W2500867121C2780796939 @default.
• W2500867121 hasConceptScore W2500867121C60644358 @default.
• W2500867121 hasConceptScore W2500867121C71924100 @default.
• W2500867121 hasConceptScore W2500867121C86803240 @default.
• W2500867121 hasIssue "2" @default.
• W2500867121 hasLocation W25008671211 @default.
• W2500867121 hasLocation W25008671212 @default.
• W2500867121 hasOpenAccess W2500867121 @default.
• W2500867121 hasPrimaryLocation W25008671211 @default.
• W2500867121 hasRelatedWork W131018879 @default.
• W2500867121 hasRelatedWork W1903063646 @default.
• W2500867121 hasRelatedWork W2319255337 @default.
• W2500867121 hasRelatedWork W2418489927 @default.
• W2500867121 hasRelatedWork W2778314188 @default.
• W2500867121 hasRelatedWork W3034923379 @default.
• W2500867121 hasRelatedWork W3174210926 @default.
• W2500867121 hasRelatedWork W396030573 @default.

• next