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- W2500876763 abstract "Twelve patients with hypercalcemia associated with various malignancy were treated with disodium clodronate (dichloromethylene diphosphonate, Cl2MDP), a potent inhibitor of osteoclastic bone resorpiton, in daily doses of 300 mg intravenously for 3-5 days (less than 7days) and oral daily doses of 1600 mg thereafter for thirty days or stopped at the patient’s death. Mean serum calcium concentration tell from 14.7±1.5 mg/dl before Cl2MDP to 9.7±1.8 mg/dl (p<0.05) after 5days. All patients responded well to the drug. The Cl2MDP was well tolerated, and adverse effects were limited to asymptomatic hypocalcemia in one patient as well as diarrhea in two patients. These study suggests that disodium clodronate is highly useful in treating hypercalcemia and inhibiting bone resorption in malignancy." @default.
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- W2500876763 date "1994-02-01" @default.
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- W2500876763 title "Treatment with Disodium Clodronate in Hypercalcemia of Malignancy" @default.
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