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- W2500925844 abstract "The study aimed to investigate the effects of Hypericum perforatum extract on the endocrine immune network factors in the immunosuppressed rat. Wistar rats were used to establish an immunosuppression model. Immunosuppressed rats received Hypericum perforatum extract suspension for 7 days at doses of 600 mg/kg (containing hyperforin at 7.2mg/kg).Endocrine immune network factors including IL-1, DA, NE, and 5-HT were determined on day 8.The results indicated that Hypericum perforatum extract affects the endocrine immune network through decreasing endogenous IL-1,dopamine (DA), norepinephrine (NE), and 5- hydroxytryptamine (5-HT) levels. Hyperforin reverses immune suppression through enhancing DA levels to inhibit B cells while promoting T cell and macrophage functions to recover immune function." @default.
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- W2500925844 date "2016-07-24" @default.
- W2500925844 modified "2023-09-30" @default.
- W2500925844 title "Effects of Hypericum perforatum extract on the endocrine immunenetwork factors in the immunosuppressed Wistar rat" @default.
- W2500925844 doi "https://doi.org/10.18805/ijar.10980" @default.
- W2500925844 hasPublicationYear "2016" @default.
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