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- W2500945444 abstract "Background & Aims The lectin pathway of complement activation is a crucial effector cascade of the innate immune response to pathogens. Cytomegalovirus (CMV) infection occurs frequently in immunocompromised patients after orthotopic liver transplantation (OLT). Single-nucleotide polymorphisms (SNPs) in the lectin pathway genes determine their liver-derived protein level and functional activity. We examined the association between these SNPs and the risk for CMV infection in OLT. Methods OLT patients ( n =295) were genotyped for recipient and donor SNPs in mannose-binding lectin ( MBL2 ), Ficolin-2 ( FCN2 ) and MBL-associated serine protease ( MASP2 ) genes. Results Combined analysis of independently associated variant MBL2 [HR 1.65, p FCN2 [1.85; p p =0.004], especially in CMV Donor−/Recipient+ (D−/R+) patients [HR 4.7 and HR 10.0, respectively, p =0.01]. A genetic donor–recipient mismatch for MBL2 and FCN2 increased the CMV risk independently, also combined [HR 5.35; p p =0.009]. Multivariate Cox analysis showed a consistent stepwise increase in CMV infection risk with the gene profile of the donor [up to HR 2.77; p MBL2 and FCN2 donor–recipient mismatch profile [up to HR 4.57; p Conclusions MBL2 and FCN2 risk alleles of donor liver and recipient constitute independent risk factors for CMV infection after OLT. Patients with these risk genes probably need intensified CMV monitoring and anti-viral therapy." @default.
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- W2500945444 date "2011-06-01" @default.
- W2500945444 modified "2023-09-26" @default.
- W2500945444 title "Mannose-Binding Lectin and Ficolin-2 Gene Polymorphisms Predispose to Cytomegalovirus (Re)Infection after Orthotopic Liver Transplantation" @default.
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