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- W2500986750 abstract "Abstract The inflammatory response in the injured spinal cord contributes importantly to secondary damage and the worsening of functional deficits. This complex, multifaceted inflammatory response is initiated within minutes after injury and extends over several weeks. Initially it involves cells that are normally resident within the central nervous system (CNS). The activation of these CNS cells triggers the recruitment and subsequent activation of various immune cells from the peripheral circulation. Inflammation is the normal response of the tissue to damage and is meant to alert the body to initiate programs to combat pathogens, clear tissue debris, repair the wound, and restore tissue homeostasis. Therefore some aspects of this response are meant to be beneficial, whereas the damaging consequences are often a bystander effect. It is therefore important to understand the factors that trigger these inflammatory responses, the cell types involved, the mechanisms underlying their recruitment and activation, and what aspects of the inflammatory response are beneficial or detrimental. Such an understanding is essential for the development of appropriate therapeutic strategies to curb the damaging effects of inflammation after spinal cord injury (SCI). The tremendous progress made since the early 2000s has led to the identification of several potential therapeutic targets to treat SCI." @default.
- W2500986750 created "2016-08-23" @default.
- W2500986750 creator A5027960258 @default.
- W2500986750 creator A5091503124 @default.
- W2500986750 date "2015-01-01" @default.
- W2500986750 modified "2023-09-25" @default.
- W2500986750 title "Inflammation and Secondary Damage after Spinal Cord Injury" @default.
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