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- W2500989511 abstract "Abstract Solvent‐mediated polymorphic transformation (SMPT) of the α ‐form into the β ‐form of taltirelin (TTL) in seeded crystallization was investigated. The kinetics of polymorph transformation of the TTL was found to be a three‐dimensional growth of nuclei mechanism by the Avrami‐Erofeev equation. The transformation from the α ‐form into the β ‐form was also studied by crystallization adding α ‐form seeds in solution. The effects of seed loading amount, temperature, supersaturation, and transformation time on polymorph transformation were evaluated. Seeded crystallization using α ‐form crystals as a seed nucleated the α ‐form TTL and then transformed the α ‐form into the β ‐form. The transformation rate was controlled by adjusting supersaturation." @default.
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- W2500989511 date "2016-06-16" @default.
- W2500989511 modified "2023-09-26" @default.
- W2500989511 title "Solvent-Mediated Polymorphic Transformation of<i>α</i>-Taltirelin by Seeded Crystallization" @default.
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- W2500989511 doi "https://doi.org/10.1002/ceat.201600043" @default.
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