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- W2501110462 endingPage "956" @default.
- W2501110462 startingPage "939" @default.
- W2501110462 abstract "Introduction: The task of discovery and development of novel therapeutic agents remains an expensive, uncertain, time-consuming, competitive, and inefficient enterprise. Due to a steady increase in the cost and time of drug development and the considerable amount of resources required, a predictive tool is needed for assessing the safety and efficacy of a new chemical entity.Areas covered: This study is focused on the high attrition rate in discovery and development of oncology and central nervous system (CNS) medicines, because the failure rate of these medicines is higher than others. Some approaches valuable in reducing attrition rates are proposed and the judicious use of biomarkers is discussed.Expert opinion: Unlike the significant progress made in identifying and characterizing novel mechanisms of disease processes and targeted therapies, the process of novel drug development is associated with an unacceptably high attrition rate. The application of clinically qualified predictive biomarkers holds great promise for further development of therapeutic targets, improved survival, and ultimately personalized medicine sets for patients. Decisions such as candidate selection, development risks, dose ranging, early proof of concept/principle, and patient stratification are based on the measurements of biologically and/or clinically validated biomarkers." @default.
- W2501110462 created "2016-08-23" @default.
- W2501110462 creator A5050037653 @default.
- W2501110462 creator A5061091304 @default.
- W2501110462 creator A5068915111 @default.
- W2501110462 date "2016-08-03" @default.
- W2501110462 modified "2023-10-15" @default.
- W2501110462 title "The development of biomarkers to reduce attrition rate in drug discovery focused on oncology and central nervous system" @default.
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