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• W2501201550 abstract "Background: A study conducted by the WHO revealed that Chennai has the highest incidence of breast carcinoma among all leading centers in India. For every two newly diagnosed case, one is dying. Early detection and treatment are the only way to prevent such deaths. Estrogen receptor (ER) progesterone receptor (PR) status, and Her2 neu (human epidermal growth factor receptor 2) overexpression study aid in deciding the treatment strategies. Study design: Cross-sectional descriptive study. Aim: To statistically evaluate the occurrence of breast lesions in patients attending Coimbatore Medical College hospital and compare it with the global census. In addition to compare ER, PRs, and Her2 neu status with the possible variables we encounter. Materials and Methods: The 368 breast specimens that were sent to the pathology department for the period of 3-year were analyzed. Both H&E stained sections and ER, PR, and Her2 neu status were reviewed by a team of experienced pathologists in our post-graduate teaching institute. Results: Totally 368 breast tumor cases were analyzed in our study. Out of that, 63.35% were malignant breast cases. Invasive ductal carcinoma (not otherwise specified [NOS]) [79%] was most commonly encountered, and most of them were grade two tumors (88.5%). The ER/PR expression was more in carcinoma in stage 1 and II and in tumors without nodal metastasis (P = 0.001). Her2 neu expression was seen more in high-grade tumors and in those with nodal metastasis (P = 0.001). There was an inverse relationship between ER/PR status and Her2 neu expression (P = 0.001). Conclusion: When compared with the western studies the ER, PR expression was low in our study group. Moreover, there was an inverse relationship between the ER, PR expression, and Her2 neu status." @default.
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• W2501201550 date "2016-01-01" @default.
• W2501201550 modified "2023-09-27" @default.
• W2501201550 title "Breast Carcinoma, Receptor Status, and Her2 neu Overexpression Revisited" @default.
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