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- W2501355506 abstract "Objective: To test the hypothesis that nitric oxide production is decreased in hyperprolactinemic, amenorrheic patients with estrogen (E) deficiency, augmenting the possible risk of cardiovascular disorders. Setting: Cairo University Hospitals. Design: Prospective, case-controlled study. Patient(s): Twenty-five galactorrheic, hyperprolactinemic patients with amenorrhea of more than 6 months and with low serum Ec, as well as 30 healthy, fertile women (controls) matched for age and body mass index. Intervention(s): Bromocriptine was administered orally to hyperprolactinemic patients, and blood samples were collected before and 6 weeks after treatment. Main Outcome Measure(s): Total nitric oxide production was determined photometrically using Greiss reagent after preliminary conversion of nitrate to nitrite by nitrate reductase. Result(s): Serum Ez and nitric oxide levels in hyperprolactinemic, amenorrheic patients (62.5 + 3.2 [SE] pg/mL [229 + 11.7 pmol/TJ and 18.4 + 2.5 pmol/L, respectively) were significantly lower than Ez (114 + 6.4 pg/mL [418 ? 23.5 pmol/L]) and nitric oxide (41.2 + 4.1 pmol/L) levels observed in normal women during the follicular phase. The decrease of nitric oxide was associated with elevation of blood pressure. Treatment of hyperprolactinemia with bromocriptine restored normal values of serum nitric oxide and Ez, and normal blood pressure. Conclusion(s): Hyperprolactinemia with E deficiency exhibits a significant decrease in nitric oxide production, and this decrease may subject the patient to certain cardiovascular disorders and disturbed ovarian function. (Fertil Sterile 1997; 68454-g. 0 1997 by American Society for Reproductive Medicine.) Galactorrhea is inappropriate lactation in nonpuerperal women. Of women with amenorrhea, regardless of its etiology, 15% to 20% exhibit elevated prolactin levels (1). The probability of hyperprolactinemia increases markedly when galactorrhea is present. Many conditions may induce hypersecretion of prolactin, including pituitary adenoma and primary hypothyroidism. Patients with amenorrhea and hyperprolactinemia frequently exhibit estrogen (E) deficiency, but in some cases substantial amounts of E may be present despite a long history of amenorrheic galactorrhea (2)." @default.
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- W2501355506 date "1997-01-01" @default.
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- W2501355506 title "Circulating nitric oxide levels in amenorrheic women galactorrheic, hyperprolactinemic," @default.
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