Matches in SemOpenAlex for { <https://semopenalex.org/work/W2501417003> ?p ?o ?g. }
- W2501417003 endingPage "63" @default.
- W2501417003 startingPage "43" @default.
- W2501417003 abstract "Knowledge of the mechanisms of prohormone processing has been growing steadily over the last decade. Studies with knockout mice have defined the individual steps of the pathways and have emphasized the physiological importance of the process. Although the phenotypes caused by deficiency of the processing enzymes have traditionally been ascribed to lack of product, they may also be caused by an oversupply of the precursor, since evidence is now accumulating that the precursors are biologically active through different receptors from the mature hormones. The processing pathways leading to the gastrointestinal hormones gastrin-releasing peptide, gastrin, and Sonic Hedgehog are presented as examples. The crystal structures of many of the processing enzymes have now been determined, their catalytic mechanisms defined, and selective inhibitors identified. Further improvements in inhibitor potency and specificity may lead to novel therapies for diseases as diverse as obesity and cancer." @default.
- W2501417003 created "2016-08-23" @default.
- W2501417003 creator A5089939339 @default.
- W2501417003 date "2012-01-01" @default.
- W2501417003 modified "2023-09-24" @default.
- W2501417003 title "Post-translational Processing of Gastrointestinal Peptides" @default.
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