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- W2501436757 abstract "This chapter discusses autoimmunity in systemic lupus erythematosus (SLE). SLE is a classic autoimmune rheumatic disease characterized by a wide variety of clinical features and a broad selection of antinuclear and other antibodies. The hallmark of the disease is widespread inflammation, which may affect virtually any organ of the body. The propensity of the disease to involve multiple organs/systems requires a multidisciplinary approach to its management. A major feature of SLE is its apparent diversity of autoantibodies. Many of these autoantibodies may present many years before the clinical diagnosis of SLE. Some of these antibodies are strongly associated with particular disease features. Antinuclear antibodies (ANA) are not specific for SLE and may be found in other conditions such as Sjogren's syndrome, polymyositis, and scleroclerma, and in 10% of normal individuals. ANA may be detected by enzyme immunoassay or more commonly by indirect immunofluorescence using tissue culture cells such as human epithelioid cells or frozen sections of rodent liver or kidney as substrate. The pattern of nuclear fluorescence is used to indicate the specificity of antibody present. The homogeneous pattern is common in SLE and may be due to anti-dsDNA or antihistone antibodies. Animal models of SLE are briefly explained." @default.
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- W2501436757 date "2005-01-01" @default.
- W2501436757 modified "2023-10-18" @default.
- W2501436757 title "Autoimmunity – Systemic Lupus Erythematosus" @default.
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- W2501436757 doi "https://doi.org/10.1016/b978-012455900-4/50306-8" @default.
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