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- W2501510958 abstract "The RNA world hypothesis refers to the early period on earth in which RNA was central in assuring both genetic continuity and catalysis. The end of this era coincided with the development of the genetic code and protein synthesis, symbolized by the apparition of the first non-random messenger RNA (mRNA). Modern transfer-messenger RNA (tmRNA) is a unique hybrid molecule which has the properties of both mRNA and transfer RNA (tRNA). It acts as a key molecule during trans-translation, a major quality control pathway of modern bacterial protein synthesis. tmRNA shares many common characteristics with ancestral RNA. Here, we present a model in which proto-tmRNAs were the first molecules on earth to support non-random protein synthesis, explaining the emergence of early genetic code. In this way, proto-tmRNA could be the missing link between the first mRNA and tRNA molecules and modern ribosome-mediated protein synthesis." @default.
- W2501510958 created "2016-08-23" @default.
- W2501510958 creator A5066154008 @default.
- W2501510958 creator A5073685709 @default.
- W2501510958 date "2016-08-02" @default.
- W2501510958 modified "2023-10-18" @default.
- W2501510958 title "Origins of tmRNA: the missing link in the birth of protein synthesis?" @default.
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- W2501510958 doi "https://doi.org/10.1093/nar/gkw693" @default.
- W2501510958 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5041485" @default.
- W2501510958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27484476" @default.
- W2501510958 hasPublicationYear "2016" @default.
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