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- W2501736315 abstract "Biological variation is used in the calculation of reference change values (RCVs) for a delta check. In this study, we examined the correlation between intra-individual biological coefficients of variation (CVI) and delta check limits according to population distribution. A total of 1,533,359 paired test results of nine routine chemistry tests were used to make the population distributions of delta percent changes. Their 0.5th, 2.5th, 97.5th, and 99.5th percentiles were then used for delta check limits. A large difference was observed between the chemistry tests in the percentage exceeding the delta check limits according to the RCVs. The mean percentage of test results of each test item exceeding the delta check limits of RCV95% ranged from 12.3% to 40.6%. Delta percent changes of protein, albumin, sodium (Na), potassium (K) and chloride (Cl) showed a symmetric distribution. However, an asymmetric distribution was observed in the delta percent changes of glucose, aspartate transaminase (AST), alanine aminotransferase (ALT) and creatinine. A good correlation was observed between CVI and the delta check limits according to population distribution and a closer correlation was observed when using the test items with CVI of < 5.0%. Intra-individual biological coefficients of variation (CVI) would be useful for the establishment of delta check limits." @default.
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- W2501736315 date "2016-12-01" @default.
- W2501736315 modified "2023-09-23" @default.
- W2501736315 title "Usefulness of biological variation in the establishment of delta check limits" @default.
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- W2501736315 doi "https://doi.org/10.1016/j.cca.2016.08.007" @default.
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