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- W2501861506 abstract "Copper is an essential trace element (ETE), critical for a variety of biologicalprocesses, for example hemoglobin synthesis, enzyme activation, particularlythat of superoxide dismutase, and, more generally, as a key component ofmitochondrial, cytoplasmic, and nuclear enzyme systems. Absorbed mainlyfrom dietary sources (organ meats, shellfish, nuts, whole-grain cereals),copper absorption and utilization is interdependent with that of other metals,including zinc, iron, cadmium, and molybdenum. Significant stores of copperare found in liver, muscle, and bone. It is required for bone formation,cardiac function, keratinization, and tissue pigmentation, where it binds toproteins, preferentially sulfur-and nitrogen-containing ligands. In mammals,ceruloplasmin (CP), a multifunctional endogenous plasma glycoprotein, isresponsible for copper transport in the blood where it may bind some 60%to 70% of the metal present. Physiological factors that require involvementof copper as a remedial factor induce CP production in the liver, thusassuring an adequate transport medium in response to increased translocation requirements (1). Total plasma copper is a reliable indicator ofcirculating CP, as a highly significant correlation exists between the twovalues (r ¼ 0.8), in rats as well as humans (2,3)." @default.
- W2501861506 created "2016-08-23" @default.
- W2501861506 creator A5047325486 @default.
- W2501861506 date "2006-08-15" @default.
- W2501861506 modified "2023-09-26" @default.
- W2501861506 title "Role of Copper in Anti-inflammatory Therapy and the Potential for Its Transdermal Application" @default.
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- W2501861506 doi "https://doi.org/10.3109/9781420009439-15" @default.
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