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• W2501897172 abstract "Animal models represent the final step to complete preclinical investigations. Here, we describe in detail the principles and procedures for the surgical, toxin-induced animal models for Parkinson’s disease (PD), and Huntington’s disease (HD). Using highly precise stereotactic intracerebral injections of toxins into the nigrostriatal pathway and basal ganglia, we are able to target specific neural circuits in different regions of the dopaminergic and GABAergic system. In addition, validated protocols for adult and neonatal cell transplantation to reconstruct the destructed neuronal circuits as models for neural repair are described." @default.
• W2501897172 created "2016-08-23" @default.
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• W2501897172 date "2016-01-01" @default.
• W2501897172 modified "2023-10-17" @default.
• W2501897172 title "Stereotactic Surgery in Rats" @default.
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• W2501897172 doi "https://doi.org/10.1007/978-1-4939-3730-1_3" @default.
• W2501897172 hasPublicationYear "2016" @default.
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