Matches in SemOpenAlex for { <https://semopenalex.org/work/W2502108981> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2502108981 endingPage "160" @default.
- W2502108981 startingPage "135" @default.
- W2502108981 abstract "The application of transition state theory to enzyme catalysis is presented in terms of mechanistic and energetic approaches. These treatments emphasize the rationale of using transition state analogs as bioactive molecules. Included in this chapter are some criteria for determining if a compound is a transition state analog. A hypothesis is then presented that the initial binding of some insecticidal carbamates and organophosphates to acetylcholinesterase is dependent in part upon their mimicking the transition state configuration of acetylcholine. As an indication of how transition state theory could be applied to problems in agricultural chemistry, we present data from this laboratory that some trifluoromethylketone inhibitors of insect juvenile hormone esterase(s) are transition state mimics and extend this argument by applying a quantitative structure-activity relationship approach to these analogs." @default.
- W2502108981 created "2016-08-23" @default.
- W2502108981 creator A5026538320 @default.
- W2502108981 creator A5080405701 @default.
- W2502108981 date "1985-04-26" @default.
- W2502108981 modified "2023-09-25" @default.
- W2502108981 title "Use of Transition-State Theory in the Development of Bioactive Molecules" @default.
- W2502108981 doi "https://doi.org/10.1021/bk-1985-0276.ch009" @default.
- W2502108981 hasPublicationYear "1985" @default.
- W2502108981 type Work @default.
- W2502108981 sameAs 2502108981 @default.
- W2502108981 citedByCount "3" @default.
- W2502108981 countsByYear W25021089812015 @default.
- W2502108981 crossrefType "book-chapter" @default.
- W2502108981 hasAuthorship W2502108981A5026538320 @default.
- W2502108981 hasAuthorship W2502108981A5080405701 @default.
- W2502108981 hasConcept C104317684 @default.
- W2502108981 hasConcept C11413529 @default.
- W2502108981 hasConcept C121332964 @default.
- W2502108981 hasConcept C13053905 @default.
- W2502108981 hasConcept C147597530 @default.
- W2502108981 hasConcept C148898269 @default.
- W2502108981 hasConcept C178790620 @default.
- W2502108981 hasConcept C181199279 @default.
- W2502108981 hasConcept C185592680 @default.
- W2502108981 hasConcept C194232998 @default.
- W2502108981 hasConcept C21951064 @default.
- W2502108981 hasConcept C2777261171 @default.
- W2502108981 hasConcept C2778816929 @default.
- W2502108981 hasConcept C32909587 @default.
- W2502108981 hasConcept C41008148 @default.
- W2502108981 hasConcept C41183919 @default.
- W2502108981 hasConcept C48103436 @default.
- W2502108981 hasConcept C55493867 @default.
- W2502108981 hasConcept C57476982 @default.
- W2502108981 hasConcept C62520636 @default.
- W2502108981 hasConcept C71220013 @default.
- W2502108981 hasConcept C71315377 @default.
- W2502108981 hasConcept C93391505 @default.
- W2502108981 hasConcept C98184364 @default.
- W2502108981 hasConceptScore W2502108981C104317684 @default.
- W2502108981 hasConceptScore W2502108981C11413529 @default.
- W2502108981 hasConceptScore W2502108981C121332964 @default.
- W2502108981 hasConceptScore W2502108981C13053905 @default.
- W2502108981 hasConceptScore W2502108981C147597530 @default.
- W2502108981 hasConceptScore W2502108981C148898269 @default.
- W2502108981 hasConceptScore W2502108981C178790620 @default.
- W2502108981 hasConceptScore W2502108981C181199279 @default.
- W2502108981 hasConceptScore W2502108981C185592680 @default.
- W2502108981 hasConceptScore W2502108981C194232998 @default.
- W2502108981 hasConceptScore W2502108981C21951064 @default.
- W2502108981 hasConceptScore W2502108981C2777261171 @default.
- W2502108981 hasConceptScore W2502108981C2778816929 @default.
- W2502108981 hasConceptScore W2502108981C32909587 @default.
- W2502108981 hasConceptScore W2502108981C41008148 @default.
- W2502108981 hasConceptScore W2502108981C41183919 @default.
- W2502108981 hasConceptScore W2502108981C48103436 @default.
- W2502108981 hasConceptScore W2502108981C55493867 @default.
- W2502108981 hasConceptScore W2502108981C57476982 @default.
- W2502108981 hasConceptScore W2502108981C62520636 @default.
- W2502108981 hasConceptScore W2502108981C71220013 @default.
- W2502108981 hasConceptScore W2502108981C71315377 @default.
- W2502108981 hasConceptScore W2502108981C93391505 @default.
- W2502108981 hasConceptScore W2502108981C98184364 @default.
- W2502108981 hasLocation W25021089811 @default.
- W2502108981 hasOpenAccess W2502108981 @default.
- W2502108981 hasPrimaryLocation W25021089811 @default.
- W2502108981 hasRelatedWork W178840922 @default.
- W2502108981 hasRelatedWork W1973420209 @default.
- W2502108981 hasRelatedWork W2029324180 @default.
- W2502108981 hasRelatedWork W2032807535 @default.
- W2502108981 hasRelatedWork W2060933931 @default.
- W2502108981 hasRelatedWork W2067387448 @default.
- W2502108981 hasRelatedWork W2073746424 @default.
- W2502108981 hasRelatedWork W2485245236 @default.
- W2502108981 hasRelatedWork W2502108981 @default.
- W2502108981 hasRelatedWork W2949912922 @default.
- W2502108981 isParatext "false" @default.
- W2502108981 isRetracted "false" @default.
- W2502108981 magId "2502108981" @default.
- W2502108981 workType "book-chapter" @default.