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- W2502121746 abstract "Primary Sjogren’s syndrome (pSS) definitely lacks any specific treatment. The only possibility for finding drugs is to evaluate their efficacy using the classic gold standard of randomized clinical trials. One could speculate whether some recent controlled trials were negative in pSS because of the inefficacy of the drug under evaluation or because of the clinical trial design adopted. Therefore the definition of the optimal outcome measures is crucial to set up new clinical trials. The difficulties to set up clinical trials in pSS are related to the large spectrum of clinical involvement (glandular/extraglandular involvement), to the absence of correlation between symptoms of dryness and function assessed by objective measurements, and between symptoms and systemic complications. Fortunately, significant improvements were recently achieved in this field; thanks to the international efforts of patients with pSS and of the community of caregivers devoted to the disease. This huge international and collaborative effort resulted in the validation of international disease activity scores. We still need to try to establish a consensus composite score which takes into account symptoms, systemic complications, and objective assessment of dryness." @default.
- W2502121746 created "2016-08-23" @default.
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- W2502121746 date "2016-01-01" @default.
- W2502121746 modified "2023-09-26" @default.
- W2502121746 title "Outcome Measures in Sjögren’s Syndrome and Perspectives in Clinical Trial Design" @default.
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- W2502121746 doi "https://doi.org/10.1016/b978-0-12-803604-4.00017-4" @default.
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